Laser-assisted delivery of vitamin c or vitamin c plus growth factors in the treatment of chloasma in women: a systematic review and meta-analysis
Main Article Content
Keywords
laser-assisted delivery, melasma, risk ratio, skin disorders, systematic review
Abstract
The use of lasers can be an effective approach for treating chloasma in women via the delivery of vitamin C and growth factors. This meta-analysis aimed to assess laser-assisted drug delivery (LADD) vs. traditional techniques for women’s skin disorders such as chloasma. According to the “Preferred Reporting Items for Systematic Reviews and Meta-Analysis” (PRISMA) guidelines, we searched the PubMed, ScienceDirect, Google Scholar, Springer, and Wiley online digital libraries. Articles published between 2000 and August 5, 2021, were included in this meta-analysis. A random-effects model was used to determine the pooled risk ratio (RR) with a 95% confidence interval (CI). This meta-analysis included a total of 16 studies. No significant heterogeneity values were observed. A subgroup analysis showed that patients receiving vitamin C plus growth factors had decreased the average wrinkle depth (AD) rates that were more significant than for the patients who received vitamin C alone. Moreover, patients in the treatment group showed greater reductions in the “Melasma Area and Severity Index” (MASI) score than in the control group. This meta-analysis suggested that the laser-assisted delivery of vitamin C plus growth factors should be widely used for certain skin diseases. Future studies need to conduct more trials with large populations using cosmeceutical or other growth factors.
References
Alvin, G., Catambay, N., Vergara A., Jamora M., 2011. A comparative study of the safety and efficacy of 75% mulberry (Morus alba) extract oil versus placebo as a topical treatment for melasma: a randomized, single-blind, placebo-controlled trial. Journal of Drugs in Dermatology 10: 1025–1031.
Badawi, A. M., Osman, M. A., 2018. Fractional erbium-doped yttrium aluminum garnet laser-assisted drug delivery of hydroquinone in the treatment of melasma. Clinical, cosmetic and investigational dermatology 11: 13. 10.2147/CCID.S147413
Bailey, A. J. M., Li, O.H., Tan, G.M., Cheng, W., Dover, S.J., 2021. Microneedling as an adjuvant to topical therapies for melasma: A systematic review and meta-analysis. Journal of the American Academy of Dermatology. 86(4): 797–810.
Bolanča, I., et al., 2008. Chloasma-the mask of pregnancy. Collegium antropologicum 32(2): 139–141.
Cheng, M., et al., 2022. Effect of dual-modified cassava starches on intelligent packaging films containing red cabbage extracts. Food Hydrocolloids 124: 107225. 10.1016/j.foodhyd.2021.107225
Choi, S., Kim, K. H., Song, K. H., 2015. Efficacy of ablative fractional laser-assisted photodynamic therapy with short-incubation time for the treatment of facial and scalp actinic keratosis: 12-month follow-up results of a randomized, prospective, comparative trial. Journal of the European Academy of Dermatology and Venereology 29: 1598–1605. 10.1111/jdv.12953
Handog, E. B., Galang, D. A. V. F., De Leon-Godinez, M. A., Chan, G. P, 2009. A randomized, double-blind, placebo-controlled trial of oral procyanidin with vitamins A, C, E for melasma among Filipino women. International journal of dermatology 48(8): 896–901. 10.1111/j.1365-4632.2009.04130.x
He, G., Liu, X., Cui, Z., 2021. Achieving global food security by focusing on nitrogen efficiency potentials and local production. Global Food Security 29: 100536. 10.1016/j.gfs.2021.100536
Higgins, J., 2011. Cochrane handbook for systematic reviews of interventions. Version 5.1. 0 [updated March 2011]. The Cochrane Collaboration. www.cochrane-handbook.org.
Hu, X., et al., 2021. AIEgens enabled ultrasensitive point-of-care test for multiple targets of food safety: Aflatoxin B1 and cyclopiazonic acid as an example. Biosensors and Bioelectronics 182: 113188. 10.1016/j.bios.2021.113188
Kim, J., Kim, J., Lee, Y. I., Almurayshid, A., Jung, J. Y., Lee, J. H., 2020. Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd: YAG laser for treatment of environment-induced skin pigmentation. Journal of cosmetic dermatology 19(10): 2576–2582. 10.1111/jocd.13323
Liang, S., Huang, K. Y., Xu, Y. T., Sun, Y. N, 2017. Acupuncture for chloasma: A systematic review and meta-analysis of randomized controlled trials. European Journal of Integrative Medicine 14: 37–45. 10.1016/j.eujim.2017.08.006
Lima, E. V., Lima, M. M. D., Paixão, M. P., Miot, H. A., 2017. Assessment of the effects of skin microneedling as adjuvant therapy for facial melasma: a pilot study. BMC dermatology 17(1): 1–6. 10.1186/s12895-017-0066-5
Lin, C.-H., Aljuffali, I. A., Fang, J. Y. , 2014. Lasers as an approach for promoting drug delivery via skin. Expert opinion on drug delivery 11(4): 599–614. 10.1517/17425247.2014.885501
Ma, S., et al., 2021. Sourdough improves the quality of whole-wheat flour products: Mechanisms and challenges-A review. Food Chemistry 360: 130038. 10.1016/j.foodchem.2021.130038
Ma, S., et al., 2022. Effect of synergistic fermentation of Lactobacillus plantarum and Saccharomyces cerevisiae on thermal properties of wheat bran dietary fiber-wheat starch system. Food Chemistry 373: 131417. 10.1016/j.foodchem.2021.131417
Machado, B. H. B., Frame, J., Zhang, J., Najlah, M., 2021a. Comparative study on the outcome of periorbital wrinkles treated with laser-assisted delivery of vitamin C or vitamin C plus growth factors: a randomized, double-blind, clinical trial. Aesthetic Plastic Surgery 45(3): 1020–1032. 10.1007/s00266-020-02035-z
Machado, B. H. B., Zhang, J., Frame, J., Najlah, M. , 2021b. Treatment of Scars with Laser-Assisted Delivery of Growth Factors and Vitamin C: A Comparative, Randomised, Double-blind, Early Clinical Trial. Aesthetic Plastic Surgery 45(5): 1–12. 10.1007/s00266-021-02232-4
Margulis, A. V., et al., 2014. Quality assessment of observational studies in a drug-safety systematic review, comparison of two tools: the Newcastle-Ottawa scale and the RTI item bank. Clinical epidemiology 6: 359. 10.2147/CLEP.S66677
Ooe, M., Seki, T., Miura, T., Takada, A., 2013. Comparative evaluation of wrinkle treatments. Aesthetic plastic surgery 37(2): 424–433. 10.1007/s00266-012-0029-5
Oresajo, C., et al., 2008. Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin. Journal of cosmetic dermatology 7(4): 290–297. 10.1111/j.1473-2165.2008.00408.x
Page, M. J., et al., 2021. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Bmj. 10(1): 1–11.
Passeron, T., Picardo, M., 2018. Melasma, a photoaging disorder. Pigment cell & melanoma research. 31: 461–465. 10.1111/pcmr.12684
Qu, Y., Wang, F., Liu, J., Xia, X., 2021. Clinical observation and dermoscopy evaluation of fractional CO2 laser combined with topical tranexamic acid in melasma treatments. Journal of Cosmetic Dermatology 20(4): 1110–1116. 10.1111/jocd.13992
Rahman, J., Yasmin, M., Shikha, F. S., Islam, M., Riad, M. I., 2019. Intercropping of potato with brinjal. Malaysian Journal of Sustainable Agriculture (MJSA) 3: 16–19. 10.26480/mjsa.02.2019.16.19
Rattanawiwatpong, P., Wanitphakdeedecha, R., Bumrungpert, A., Maiprasert, M., 2020. Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial. Journal of cosmetic dermatology 19: 671–676. 10.1111/jocd.13305
Robati, R. M., Asadi, E., 2017. Efficacy and safety of fractional CO2 laser versus fractional Er: YAG laser in the treatment of facial skin wrinkles. Lasers in medical science 32: 283–289. 10.1007/s10103-016-2111-8
Sapkota, S., Gyawali, C. , Effect of different methods of crop establishment on growth and yield of a spring rice at Janakpurdham-17, Dhanusha. Malaysian Journal of Sustainable Agriculture 4(1): 10–15.
Sharma, N., Sharma, S., Singh, B., Kaur, G., 2020. Stability evaluation of iron and vitamin A during processing and storage of fortified pasta. Quality Assurance and Safety of Crops & Foods 12: 50–60. 10.15586/QAS2019.656
Sharmin, T., Ahmed, N., 2021. Development Of Nata De Coco And Strawberry Flavored Nata De Coco Drink And Comparative Quality Evaluation. Science Heritage Journal (GWS) 5: 34–40. 10.26480/gws.02.2021.34.40
Simmonds, M., 2015. Quantifying the risk of error when interpreting funnel plots. Systematic reviews 4: 1–7. 10.1186/s13643-015-0004-8
Tang, X., et al., 2020. Competitive-type pressure-dependent immunosensor for highly sensitive detection of diacetoxyscirpenol in wheat via monoclonal antibody. Analytical chemistry 92(5): 3563–3571. 10.1021/acs.analchem.9b03933
Ustuner, P., Balevi, A., Ozdemir, M., 2017. A split-face, investigator-blinded comparative study on the efficacy and safety of Q-switched Nd: YAG laser plus microneedling with vitamin C versus Q-switched Nd: YAG laser for the treatment of recalcitrant melasma. Journal of Cosmetic and Laser Therapy 19: 7.383–390. 10.1080/14764172.2017.1342036
Waibel, J. S., et al., 2016. Laser-assisted delivery of vitamin C, vita-min E, and ferulic acid formula serum decreases fractional laser postoperative recovery by increased beta fibroblast growth factor expression. Lasers in surgery and medicine 48(3): 238–244. 10.1002/lsm.22448
Wang, X., Li, Z., Zhang, D., Li, L., Sophie, S., 2014. A double-blind, placebo controlled clinical trial evaluating the efficacy and safety of a new skin whitening combination in patients with chloasma. Journal of cosmetics, dermatological sciences and applications 4: 92–98. 10.4236/jcdsa.2014.42014
Wang, Z., et al., 2021. Effects of thermal properties and behavior of wheat starch and gluten on their interaction: A review. International journal of biological macromolecules 177: 474–484. 10.1016/j.ijbiomac.2021.02.175
Wenande, E., Anderson, R. R., Haedersdal, M., 2020. Fundamentals of fractional laser-assisted drug delivery: An in-depth guide to experimental methodology and data interpretation. Advanced drug delivery reviews 153: 169–184. 10.1016/j.addr.2019.10.003
Yang, L., et al., 2022. Na+/Ca2+ induced the migration of soy hull polysaccharides in the mucus layer in vitro. International Journal of Biological Macromolecules 199: 331–340. 10.1016/j.ijbiomac.2022.01.016
Badawi, A. M., Osman, M. A., 2018. Fractional erbium-doped yttrium aluminum garnet laser-assisted drug delivery of hydroquinone in the treatment of melasma. Clinical, cosmetic and investigational dermatology 11: 13. 10.2147/CCID.S147413
Bailey, A. J. M., Li, O.H., Tan, G.M., Cheng, W., Dover, S.J., 2021. Microneedling as an adjuvant to topical therapies for melasma: A systematic review and meta-analysis. Journal of the American Academy of Dermatology. 86(4): 797–810.
Bolanča, I., et al., 2008. Chloasma-the mask of pregnancy. Collegium antropologicum 32(2): 139–141.
Cheng, M., et al., 2022. Effect of dual-modified cassava starches on intelligent packaging films containing red cabbage extracts. Food Hydrocolloids 124: 107225. 10.1016/j.foodhyd.2021.107225
Choi, S., Kim, K. H., Song, K. H., 2015. Efficacy of ablative fractional laser-assisted photodynamic therapy with short-incubation time for the treatment of facial and scalp actinic keratosis: 12-month follow-up results of a randomized, prospective, comparative trial. Journal of the European Academy of Dermatology and Venereology 29: 1598–1605. 10.1111/jdv.12953
Handog, E. B., Galang, D. A. V. F., De Leon-Godinez, M. A., Chan, G. P, 2009. A randomized, double-blind, placebo-controlled trial of oral procyanidin with vitamins A, C, E for melasma among Filipino women. International journal of dermatology 48(8): 896–901. 10.1111/j.1365-4632.2009.04130.x
He, G., Liu, X., Cui, Z., 2021. Achieving global food security by focusing on nitrogen efficiency potentials and local production. Global Food Security 29: 100536. 10.1016/j.gfs.2021.100536
Higgins, J., 2011. Cochrane handbook for systematic reviews of interventions. Version 5.1. 0 [updated March 2011]. The Cochrane Collaboration. www.cochrane-handbook.org.
Hu, X., et al., 2021. AIEgens enabled ultrasensitive point-of-care test for multiple targets of food safety: Aflatoxin B1 and cyclopiazonic acid as an example. Biosensors and Bioelectronics 182: 113188. 10.1016/j.bios.2021.113188
Kim, J., Kim, J., Lee, Y. I., Almurayshid, A., Jung, J. Y., Lee, J. H., 2020. Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd: YAG laser for treatment of environment-induced skin pigmentation. Journal of cosmetic dermatology 19(10): 2576–2582. 10.1111/jocd.13323
Liang, S., Huang, K. Y., Xu, Y. T., Sun, Y. N, 2017. Acupuncture for chloasma: A systematic review and meta-analysis of randomized controlled trials. European Journal of Integrative Medicine 14: 37–45. 10.1016/j.eujim.2017.08.006
Lima, E. V., Lima, M. M. D., Paixão, M. P., Miot, H. A., 2017. Assessment of the effects of skin microneedling as adjuvant therapy for facial melasma: a pilot study. BMC dermatology 17(1): 1–6. 10.1186/s12895-017-0066-5
Lin, C.-H., Aljuffali, I. A., Fang, J. Y. , 2014. Lasers as an approach for promoting drug delivery via skin. Expert opinion on drug delivery 11(4): 599–614. 10.1517/17425247.2014.885501
Ma, S., et al., 2021. Sourdough improves the quality of whole-wheat flour products: Mechanisms and challenges-A review. Food Chemistry 360: 130038. 10.1016/j.foodchem.2021.130038
Ma, S., et al., 2022. Effect of synergistic fermentation of Lactobacillus plantarum and Saccharomyces cerevisiae on thermal properties of wheat bran dietary fiber-wheat starch system. Food Chemistry 373: 131417. 10.1016/j.foodchem.2021.131417
Machado, B. H. B., Frame, J., Zhang, J., Najlah, M., 2021a. Comparative study on the outcome of periorbital wrinkles treated with laser-assisted delivery of vitamin C or vitamin C plus growth factors: a randomized, double-blind, clinical trial. Aesthetic Plastic Surgery 45(3): 1020–1032. 10.1007/s00266-020-02035-z
Machado, B. H. B., Zhang, J., Frame, J., Najlah, M. , 2021b. Treatment of Scars with Laser-Assisted Delivery of Growth Factors and Vitamin C: A Comparative, Randomised, Double-blind, Early Clinical Trial. Aesthetic Plastic Surgery 45(5): 1–12. 10.1007/s00266-021-02232-4
Margulis, A. V., et al., 2014. Quality assessment of observational studies in a drug-safety systematic review, comparison of two tools: the Newcastle-Ottawa scale and the RTI item bank. Clinical epidemiology 6: 359. 10.2147/CLEP.S66677
Ooe, M., Seki, T., Miura, T., Takada, A., 2013. Comparative evaluation of wrinkle treatments. Aesthetic plastic surgery 37(2): 424–433. 10.1007/s00266-012-0029-5
Oresajo, C., et al., 2008. Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin. Journal of cosmetic dermatology 7(4): 290–297. 10.1111/j.1473-2165.2008.00408.x
Page, M. J., et al., 2021. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Bmj. 10(1): 1–11.
Passeron, T., Picardo, M., 2018. Melasma, a photoaging disorder. Pigment cell & melanoma research. 31: 461–465. 10.1111/pcmr.12684
Qu, Y., Wang, F., Liu, J., Xia, X., 2021. Clinical observation and dermoscopy evaluation of fractional CO2 laser combined with topical tranexamic acid in melasma treatments. Journal of Cosmetic Dermatology 20(4): 1110–1116. 10.1111/jocd.13992
Rahman, J., Yasmin, M., Shikha, F. S., Islam, M., Riad, M. I., 2019. Intercropping of potato with brinjal. Malaysian Journal of Sustainable Agriculture (MJSA) 3: 16–19. 10.26480/mjsa.02.2019.16.19
Rattanawiwatpong, P., Wanitphakdeedecha, R., Bumrungpert, A., Maiprasert, M., 2020. Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial. Journal of cosmetic dermatology 19: 671–676. 10.1111/jocd.13305
Robati, R. M., Asadi, E., 2017. Efficacy and safety of fractional CO2 laser versus fractional Er: YAG laser in the treatment of facial skin wrinkles. Lasers in medical science 32: 283–289. 10.1007/s10103-016-2111-8
Sapkota, S., Gyawali, C. , Effect of different methods of crop establishment on growth and yield of a spring rice at Janakpurdham-17, Dhanusha. Malaysian Journal of Sustainable Agriculture 4(1): 10–15.
Sharma, N., Sharma, S., Singh, B., Kaur, G., 2020. Stability evaluation of iron and vitamin A during processing and storage of fortified pasta. Quality Assurance and Safety of Crops & Foods 12: 50–60. 10.15586/QAS2019.656
Sharmin, T., Ahmed, N., 2021. Development Of Nata De Coco And Strawberry Flavored Nata De Coco Drink And Comparative Quality Evaluation. Science Heritage Journal (GWS) 5: 34–40. 10.26480/gws.02.2021.34.40
Simmonds, M., 2015. Quantifying the risk of error when interpreting funnel plots. Systematic reviews 4: 1–7. 10.1186/s13643-015-0004-8
Tang, X., et al., 2020. Competitive-type pressure-dependent immunosensor for highly sensitive detection of diacetoxyscirpenol in wheat via monoclonal antibody. Analytical chemistry 92(5): 3563–3571. 10.1021/acs.analchem.9b03933
Ustuner, P., Balevi, A., Ozdemir, M., 2017. A split-face, investigator-blinded comparative study on the efficacy and safety of Q-switched Nd: YAG laser plus microneedling with vitamin C versus Q-switched Nd: YAG laser for the treatment of recalcitrant melasma. Journal of Cosmetic and Laser Therapy 19: 7.383–390. 10.1080/14764172.2017.1342036
Waibel, J. S., et al., 2016. Laser-assisted delivery of vitamin C, vita-min E, and ferulic acid formula serum decreases fractional laser postoperative recovery by increased beta fibroblast growth factor expression. Lasers in surgery and medicine 48(3): 238–244. 10.1002/lsm.22448
Wang, X., Li, Z., Zhang, D., Li, L., Sophie, S., 2014. A double-blind, placebo controlled clinical trial evaluating the efficacy and safety of a new skin whitening combination in patients with chloasma. Journal of cosmetics, dermatological sciences and applications 4: 92–98. 10.4236/jcdsa.2014.42014
Wang, Z., et al., 2021. Effects of thermal properties and behavior of wheat starch and gluten on their interaction: A review. International journal of biological macromolecules 177: 474–484. 10.1016/j.ijbiomac.2021.02.175
Wenande, E., Anderson, R. R., Haedersdal, M., 2020. Fundamentals of fractional laser-assisted drug delivery: An in-depth guide to experimental methodology and data interpretation. Advanced drug delivery reviews 153: 169–184. 10.1016/j.addr.2019.10.003
Yang, L., et al., 2022. Na+/Ca2+ induced the migration of soy hull polysaccharides in the mucus layer in vitro. International Journal of Biological Macromolecules 199: 331–340. 10.1016/j.ijbiomac.2022.01.016
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Aug 3, 2022
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