Physicochemical and biological activities of polysaccharides from the waste residue of sea cucumber peptide production
Main Article Content
Keywords
anti-tumour activities, sea cucumber peptide, sea cucumber polysaccharides, waste residue
Abstract
This study was to investigate the physicochemical and biological activities of sea cucumber polysaccharides extracted from waste residue of peptide production (SCRP). The monosaccharide composition of SCRP was 20.03% mannose, 19.56% glucose, 18.63% galactose, 25.94% arabinose and 15.82% fucose with the Mw and Mn of SCRP of 57.5 and 51.3 kDa. The intrinsic viscosity of SCRP was 8.9 mL/mg with a liquid-like rheological behaviour. Two main endothermic peak temperatures of the SCRP sample were 85.03 and 231.80°C. SCRP rendered the early apoptosis of cells, as well as induced the loss of mitochondrial transmembrane potential and increase the reactive oxygen species (ROS) level with a concentration-dependence manner. The results implied that a by-product SCRP could be extracted from the waste residue during peptide production, and exhibited inhibitory effects against MDA-MB-231 cells.
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Dodgson, K. and Price, R., 1962. A note on the determination of the ester sulphate content of sulphated polysaccharides. Biochemical Journal 84: 106–110. 10.1042/bj0840106
Doynikova, A.N. and Vekshin, N.L., 2019. Fluorescent determination of micro-quantities of RNA using Hoechst 33258 and binase. Analytical Biochemistry 576: 5–8. 10.1016/j.ab.2019.04.002
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Li, Q., Che, H.-X., Wang, C.-C., Zhang, L.-Y., Ding, L., Xue, C.-H., Zhang, T.-T. and Wang, Y.-M., 2019. Cerebrosides from sea cucumber improved Aβ1–42-induced cognitive deficiency in a rat model of Alzheimer’s disease. Molecular Nutrition & Food Research 63: 1800707. 10.1002/mnfr.201800707
Lin, F. and Pomeranz, Y., 1968. Effect of borate on colorimetric determinations of carbohydrates by the phenol-sulfuric acid method. Analytical Biochemistry 24: 128–131. 10.1016/0003-2697(68)90067-5
Lin, L.Z., Kun, Y., Lin, Z., Ming, Z.M., Zheng, S.W., Yuan, Z.Q. and Jun, L.S., 2018. Anti-aging effect of sea cucumber (Cucumaria frondosa) hydrolysate on fruit flies and d-galactose-induced aging mice. Journal of Functional Foods 47: 11–18. 10.1016/j.jff.2018.05.033
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Liu, X., Sun, Z.L., Zhang, M.S., Meng, X.M., Xia, X.K., Yuan, W.P., Xue, F. and Liu, C.H., 2012. Antioxidant and antihyperlipidemic activities of polysaccharides from sea cucumber Apostichopus japonicus. Carbohydrate Polymers 90: 1664–1670. 10.1016/j.carbpol.2012.07.047
Lu, Y. and Wang, B.L., 2009. The research progress of antitumorous effectiveness of Stichopus japonicus acid mucopolysaccharide in North of China. The American Journal of the Medical Sciences 337: 195–198. 10.1097/MAJ.0b013e318182ee45
Mathur, A., Hong, Y., Kemp, B.K., Barrientos, A.A. and Erusalimsky, J.D., 2000. Evaluation of fluorescent dyes for the detection of mitochondrial membrane potential changes in cultured cardiomyocytes. Cardiovascular Research 46: 126–138. 10.1016/S0008-6363(00)00002-X
Myron, P., Siddiquee, S. and Azad, S.A., 2017. Partial structural studies of fucosylated chondroitin sulfate (FuCS) using attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and chemometrics. Vibrational Spectroscopy 89: 26–36. 10.1016/j.vibspec.2016.12.008
Pérez-Vega, J.A., Olivera-Castillo, L., Gómez-Ruiz, J.Á. and Hernández-Ledesma, B., 2013. Release of multifunctional peptides by gastrointestinal digestion of sea cucumber (Isostichopus badionotus). Journal of Functional Foods 5: 869–877. 10.1016/j.jff.2013.01.036
Pollard, J., Rajabi-Siahboomi, A., Badhan, R.K.S., Mohammed, A.R. and Perrie, Y., 2019. High-throughput screening of excipients with a biological effect: a kinetic study on the effects of surfactants on efflux-mediated transport. Journal of Pharmacy and Pharmacology 71: 889–897. 10.1111/jphp.13072
Rajpurohit, R., Mansfield, K., Ohyama, K., Ewert, D. and Shapiro, I., 1999. Chondrocyte death is linked to development of a mitochondrial membrane permeability transition in the growth plate. Journal of Cellular Physiology 179: 287–296. 10.1002/(SICI)1097-4652(199906)179:3<287::AID-JCP6>3.0.CO;2-T
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Siegel, R.L., Miller, K.D. and Jemal, A., 2016. Cancer statistics, 2016. CA: A Cancer Journal for Clinicians 66: 7–30. 10.3322/caac.21332
Sinha, K., Das, J., Pal, P.B. and Sil, P.C., 2013. Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis. Archives of Toxicology 87: 1157–1180. 10.1007/s00204-013-1034-4
Song, S., Wu, S.F., Ai, C.Q., Xu, X., Zhu, Z.J., Cao, C.Y., Yang, J.F. and Wen, C.R., 2018. Compositional analysis of sulfated polysaccharides from sea cucumber (Stichopus japonicus) released by autolysis reaction. International Journal of Biological Macromolecules 114: 420–425. 10.1016/j.ijbiomac.2018.03.137
Sun, Y.J., Gong, G.P., Guo, Y.M., Wang, Z.F., Song, S., Zhu, B.W., Zhao, L.L. and Jiang, J.J., 2018. Purification, structural features and immunostimulatory activity of novel polysaccharides from Caulerpa lentillifera. International Journal of Biological Macromolecules 108: 314–323. 10.1016/j.ijbiomac.2017.12.016
Szeleszczuk, Ł., Pisklak, D.M., Zielińska-Pisklak, M. and Jurczak, E., 2019. A new polymorph of 17-β-estradiol and the application of different analytical techniques (ssNMR, PXRD, DSC, and FTIR) for its study. Journal of Molecular Structure 1183: 274–280. 10.1016/j.molstruc.2019.01.102
Tang, Y.J., Zhao, H., Yao, J.H., Zhu, Z.H., Sun, D.H. and Zhang, M., 2019. A doxorubicin and vincristine drug release system based on magnetic PLGA microspheres prepared by coaxial electrospray. Journal of Materials Science 54: 9689–9706. 10.1007/s10853-019-03575-9
Thinh, P.D., Ly, B.M., Usoltseva, R.V., Shevchenko, N.M., Rasin, A.B., Anastyuk, S.D., Malyarenko, O.S., Zvyagintseva, T.N., San, P.T. and Ermakova, S.P., 2018. A novel sulfated fucan from Vietnamese sea cucumber Stichopus variegatus: isolation, structure and anticancer activity in vitro. International Journal of Biological Macromolecules 117: 1101–1109. 10.1016/j.ijbiomac.2018.06.017
Ustyuzhanina, N.E., Bilan, M.I., Dmitrenok, A.S., Borodina, E.Y., Stonik, V.A., Nifantiev, N.E. and Usov, A.I., 2017. A highly regular fucosylated chondroitin sulfate from the sea cucumber Massinium magnum: structure and effects on coagulation. Carbohydrate Polymers 167: 20–26. 10.1016/j.carbpol.2017.02.101
Vaikundamoorthy, R., Krishnamoorthy, V., Vilwanathan, R. and Rajendran, R., 2018. Structural characterization and anticancer activity (MCF7 and MDA-MB-231) of polysaccharides fractionated from brown seaweed Sargassum wightii. International Journal of Biological Macromolecules 111: 1229–1237. 10.1016/j.ijbiomac.2018.01.125
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