Main Article Content
essential elements, food safety, fruits, health risk assessments, nutritional assessment
Fruits could contain elements in various concentrations, which can have both positive and negative impacts on human health. The concentrations of essential elements, including Iron (Fe), Copper (Cu), Zinc (Zn), Manganese (Mn), and Chromium (Cr) in five types of fruits, namely, peach, apple, grape, nectarine, and golden plum, and the soil and irrigation water from six industrial zones of Markazi province, Iran, were evaluated using an inductively coupled plasma-optical emission spectroscopy (ICP-OES) technique. The noncarcinogenic risk was assessed by determining the target hazard quotient and the Monte Carlo simulation model. The highest concentrations of Fe, Mn, and Cr were observed in golden plum, while the highest concentrations of Cu and Zn were noted in grape and apple, respectively. The order of the mean of concentrations of elements in the soil and water samples were Fe > Mn > Zn > Cu > Cr. The transfer factor (TF) results indicate that studied fruits could not absorb a high amount of these elements from the soil (TF < 1). Target hazard quotient values of these elements in both adults and children were ranked as Cr > Cur > Fe > Mn > Zn. The target hazard quotient was 95% and total target hazard quotient was <1, meaning that the consumption of fruits is safe for consumers.
Abdelkareem, A.A.M., Mahmoud, M.H.H., Ali, D.M.H., Khalid, M.A.A., Alotaibi, S.H.M. and Elsheikh, MAA., 2018. Essential and toxic heavy metals status in some fruits from Turaba District (Saudi Arabia). Health Risk Assessment. Science, Technology & Public Policy 2: 26.
Aberournand, A., 2012. Energy and nutrient intake and food diets among Iranian University students. American Journal of Food Technology 7: 880–885. 10.3923/ajft.2012.380.385
Abtahi, M., Fakhri, Y., Oliveri Conti, G., Keramati, H., Zandsalimi, Y., Bahmani, Z., Hosseini Pouya, R., Sarkhosh, M., Moradi, B. and Amanidaz, N., 2017. Heavy metals (As, Cr, Pb, Cd, and Ni) concentrations in rice (Oryza sativa) from Iran and associated risk assessment: a systematic review. Toxin Reviews 36: 331–341. 10.1080/15569543.2017.1354307
Adel, M., Dadar, M., Fakhri, Y., Oliveri Conti, G. and Ferrante, M., 2016. Heavy metal concentration in muscle of pike (Esox lucius Linnaeus, 1758) from Anzali international wetland, southwest of the Caspian Sea and their consumption risk assessment. Toxin Reviews 35: 217–223. 10.1080/15569543.2016.1223694
Akbari, M., Moosazadeh, M., Tabrizi, R., Khatibi, S.R., Khodadost, M., Heydari, S.T., Tahami, A.N. and Lankarani, K.B., 2017. Estimation of iron deficiency anemia in Iranian children and adolescents: a systematic review and meta-analysis. Hematology (Amsterdam, Netherlands) 22: 231–239. 10.1080/10245332.2016.1240933
Ali, A.S.M., Ahmed, H.A.M., Emara, H.A.E.-A., Janjua, M.N. and Alhafez, N., 2019. Estimation and bio-availability of toxic metals between soils and plants. Polish Journal of Environmental Studies 28: 15–24. 10.15244/pjoes/81690
Araújo, S., Matos, C., Correia, E. and Antunes, M., 2019. Evaluation of phytochemicals content, antioxidant activity and mineral composition of selected edible flowers. Quality Assurance and Safety of Crops & Foods 11: 471–478. 10.3920/QAS2018.1497
Bagdatlioglu, N., Nergiz, C. and Ergonul, P.G., 2010. Heavy metal levels in leafy vegetables and some selected fruits. Journal für Verbraucherschutz und Lebensmittelsicherheit 5: 421–428. 10.1007/s00003-010-0594-y
Bailey, R.L., West Jr, K.P. and Black, R.E., 2015. The epidemiology of global micronutrient deficiencies. Annals of Nutrition and Metabolism 66: 22–33. 10.1159/000371618
Basha, A.M., Yasovardhan, N., Satyanarayana, S.V., Reddy, G.V.S. and Kumar, A.V., 2014. Trace metals in vegetables and fruits cultivated around the surroundings of Tummalapalle uranium mining site, Andhra Pradesh, India. Toxicology Reports 1: 505–512. 10.1016/j.toxrep.2014.07.011
Bost, M., Houdart, S., Oberli, M., Kalonji, E., Huneau, J.-F. and Margaritis, I., 2016. Dietary copper and human health: current evidence and unresolved issues. Journal of Trace Elements in Medicine and Biology 35: 107–115. 10.1016/j.jtemb.2016.02.006
Brown, K.H., Wuehler, S.E. and Peerson, J.M., 2001. The importance of zinc in human nutrition and estimation of the global prevalence of zinc deficiency. Food and Nutrition Bulletin 22: 113–125. 10.1177/156482650102200201
Chen, M.-J., Hsu, H.-T., Lin, C.-L. and Ju, W.-Y., 2012. A statistical regression model for the estimation of acrylamide concentrations in French fries for excess lifetime cancer risk assessment. Food and Chemical Toxicology 50: 3867–3876. 10.1016/j.fct.2012.07.010
Clarkson, P.M., 1991. Nutritional ergogenic aids: chromium, exercise, and muscle mass. International Journal of Sport Nutrition 1: 289–293. 10.1123/ijsn.1.3.289
Dadar, M., Adel, M., Nasrollahzadeh Saravi, H. and Fakhri, Y., 2017. Trace element concentration and its risk assessment in common kilka (Clupeonella cultriventris caspia Bordin, 1904) from southern basin of Caspian Sea. Toxin Reviews 36: 222–227. 10.1080/15569543.2016.1274762
Derakhshan, Z., Faramarzian, M., Mahvi, A., Hosseini, M. and Miri, M., 2016. Assessment of heavy metals residue in edible vegetables distributed in Shiraz, Iran. Journal of Food Quality and Hazards Control 3: 25–29.
Duran, A., Tuzen, M. and Soylak, M., 2008. Trace element levels in some dried fruit samples from Turkey. International Journal of Food Sciences and Nutrition 59: 581–589. 10.1080/13561820701507910
Ehsani, A., Ebadi, A., Shariatifar, N., Mojaddar, N. and Azimi, M., 2015. Assessment of some heavy metals in fruits and vegetables collected from markets in Urmia. International Journal of Current Science 15S: 78–84
Ennaji, W., Barakat, A., El Baghdadi, M. and Rais, J., 2020. Heavy metal contamination in agricultural soil and ecological risk assessment in the northeast area of Tadla plain, Morocco. Journal of Sedimentary Environments 5: 307–320. 10.1007/s43217-020-00020-9
EPA, 2012. Quantitative risk assessment calculations. Sustainable futures/P2 framework manual 2012 EPA-748-B12-001 13. Quantitative Risk Assessment Calculations 13: 1–11.
EPA, 2017. Regional screening level (RSL) summary table (TR=1E-06, HQ=1) November 2017. regional screening levels (RSLs) – generic tables. Available at: https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables
Fakhri, Y., Mousavi Khaneghah, A., Hadiani, M.R., Keramati, H., Hosseini Pouya, R., Moradi, B. and da Silva, B.S., 2017. Non-carcinogenic risk assessment induced by heavy metals content of the bottled water in Iran. Toxin Reviews 36: 313–321. 10.1080/15569543.2017.1358747
Fan, M., Margenot, A.J., Zhang, H., Lal, R., Wu, J., Wu, P., Chen, F. and Gao, C., 2020. Distribution and source identification of potentially toxic elements in agricultural soils through high-resolution sampling. Environmental Pollution 263: 114527. 10.1016/j.envpol.2020.114527
Fathabad, A.E., Shariatifar, N., Moazzen, M., Nazmara, S., Fakhri, Y., Alimohammadi, M., Azari, A. and Khaneghah, A.M., 2018. Determination of heavy metal content of processed fruit products from Tehran’s market using ICP-OES: a risk assessment study. Food and Cchemical Toxicology 115: 436–446. 10.1016/j.fct.2018.03.044
Fijałkowski, K., Kacprzak, M., Grobelak, A. and Placek, A., 2012. The influence of selected soil parameters on the mobility of heavy metals in soils. Inżynieria i Ochrona środowiska 15: 81–92.
Ghasemidehkordi, B., Malekirad, A.A., Nazem, H., Fazilati, M., Salavati, H. and Rezaei, M., 2018a. Arsenic and boron levels in irrigation water, soil, and green leafy vegetables. International Journal of Vegetable Science 24: 115–121.
Ghasemidehkordi, B., Malekirad, A.A., Nazem, H., Fazilati, M., Salavati, H., Shariatifar, N., Rezaei, M., Fakhri, Y. and Khaneghah, A.M., 2018b. Concentration of lead and mercury in collected vegetables and herbs from Markazi province, Iran: a non-carcinogenic risk assessment. Food and Chemical Toxicology 113: 204–210. 10.1080/19315260.2017.1356896
Grembecka, M. and Szefer, P., 2013. Comparative assessment of essential and heavy metals in fruits from different geographical origins. Environmental Monitoring and Assessment 185: 9139–9160. 10.1007/s10661-013-3242-z
Hashemi, M., Salehi, T., Aminzare, M., Raeisi, M. and Afshari, A., 2017. Contamination of toxic heavy metals in various foods in Iran: a review. Journal of Pharmaceutical Sciences and Research 9: 1692–1697.
Hatamikiya, M., Dorosti, N. and Mahnaz, Z., 2018. A survey of sampling of heavy metals (lead, cadmium, copper, nickel and mercury) in some cultivated vegetables in Khoramabad city and Aleshtar, Summer 2017. Yafteh 20: 1–12.
Heidari, F., Hosseini, S.M. and Bahramifar, N., 2014. Accumulation of heavy metals in soil, leaf and fruit of, Malus domestica, Elaeagnus angustifolia and Pyrus communis trees around a Zinc Factory in Zanjan, Iran. Journal of Biodiversity and Ecological Sciences 4: 15–28.
Horning, K.J., Caito, S.W., Tipps, K.G., Bowman, A.B. and Aschner, M., 2015. Manganese is essential for neuronal health. Annual Review of Nutrition 35: 71–108. 10.1146/annurev-nutr-071714-034419
IOM, 2001. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. The National Academies Press, Washington, DC. 10.17226/10026
Khan, S., Farooq, R., Shahbaz, S., Khan, M.A. and Sadique, M., 2009. Health risk assessment of heavy metals for population via consumption of vegetables. World Applied Sciences Journal 6: 1602–1606.
Kooner, R., Mahajan, B. and Dhillon, W., 2014. Heavy metal contamination in vegetables, fruits, soil and water-a critical review. International Journal of Agriculture, Environment and Biotechnology 7: 603. 10.5958/2230-732X.2014.01365.5
Korkmaz, C., Ay, Ö., Çolakfakıoğlu, C. and Erdem, C., 2019a. Heavy metal levels in some edible crustacean and mollusk species marketed in Mersin. Thalassas: An International Journal of Marine Sciences 35: 65–71. 10.1007/s41208-018-0086-x
Korkmaz, C., Ay, Ö., Ersoysal, Y., Köroğlu, M.A. and Erdem, C., 2019b. Heavy metal levels in muscle tissues of some fish species caught from north-east Mediterranean: Evaluation of their effects on human health. Journal of Food Composition and Analysis 81: 1–9. 10.1016/j.jfca.2019.04.005
Lato, A., Radulov, I., Berbecea, A., Lato, K. and Crista, F., 2012. The transfer factor of metals in soil-plant system. Research Journal of Agricultural Science 44: 67–72.
Li, F.K., Gong, A.J., Qiu, L.N., Zhang, W.W., Li, J.R., Liu, Y., Li, J.D., Gao, G. and Yuan, X.T., 2019. Determination of trace rare earth elements in fruits by microwave digestion coupled with inductively coupled plasma optical emission spectrometry. Microchemical Journal 147: 93-101.
Maleki, A., Amini, H., Nazmara, S., Zandi, S. and Mahvi, A.H., 2014. Spatial distribution of heavy metals in soil, water, and vegetables of farms in Sanandaj, Kurdistan, Iran. Journal of Environmental Health Science and Engineering 12: 136. 10.1186/s40201-014-0136-0
Maleki, A. and Zarasvand, M.A., 2008. Heavy metals in selected edible vegetables and estimation of their daily intake in Sanandaj, Iran. Southeast Asian Journal of Tropical Medicine and Public Health 39: 335.
McArdle, H.J. and Ashworth, C.J., 1999. Micronutrients in fetal growth and development. British Medical Bulletin 55: 499–510. 10.1258/0007142991902574
Micó, C., Recatalá, L., Peris, M. and Sánchez, J., 2006. Assessing heavy metal sources in agricultural soils of an European Mediterranean area by multivariate analysis. Chemosphere 65: 863–872. 10.1016/j.chemosphere.2006.03.016
Mirecki, N., Agic, R., Sunic, L., Milenkovic, L. and Ilic, S., 2015. Transfer factor as indicator of heavy metals content in plants. Fresenius Environmental Bulletin 24: 4212–4219.
Noulas, C., Tziouvalekas, M. and Karyotis, T., 2018. Zinc in soils, water and food crops. Journal of Trace Elements in Medicine and Biology 49: 252–260. 10.1016/j.jtemb.2018.02.009
Pipoyan, D., Beglaryan, M., Stepanyan, S. and Merendino, N., 2019. Dietary exposure assessment of potentially toxic trace elements in fruits and vegetables sold in town of Kapan, Armenia. Biological Trace Element Research 190: 234–241. 10.1007/s12011-018-1522-8
Prakash, D., Upadhyay, G., Gupta, C., Pushpangadan, P. and Singh, K., 2012. Antioxidant and free radical scavenging activities of some promising wild edible fruits. International Food Research Journal 19: 1109–1116.
Prohaska, J.R. and Lukasewycz, O.A., 1990. Effects of copper deficiency on the immune system, antioxidant nutrients and immune functions. Springer, Boston, pp. 123–143.
Qu, C.-S., Ma, Z.-W., Yang, J., Liu, Y., Bi, J. and Huang, L., 2012. Human exposure pathways of heavy metals in a lead-zinc mining area, Jiangsu Province, China. PLoS One 7: e46793. 10.1371/journal.pone.0046793
Qureshi, A.S., Hussain, M.I., Ismail, S. and Khan, Q.M., 2016. Evaluating heavy metal accumulation and potential health risks in vegetables irrigated with treated wastewater. Chemosphere 163: 54–61. 10.1016/j.chemosphere.2016.07.073
Rezaei, M., Farahani, S., Karimi, F., Eshghi, N., Ghasemikhah, R., Abbasi, A., Mohammadpourfard, I. and Jafari, M.J.T.R., 2016. Essential elements content of hen egg-white in Markazi province (Iran). Toxin Reviews 35: 29–32. 10.1080/15569543.2016.1180304
Rezaei, M., Shariatifar, N., Shoeibi, S., Ahmadi, M.A. and Khaniki, G.J., 2017. Simultaneous determination of residue from 58 pesticides in the wheat flour consumed in Tehran, Iran by GC/MS. Iranian Journal of Pharmaceutical Research 16: 1048.
Ru, Q.-M., Feng, Q. and He, J.-Z., 2013. Risk assessment of heavy metals in honey consumed in Zhejiang province, southeastern China. Food and Chemical Toxicology 53: 256–262. 10.1016/j.fct.2012.12.015
Sajib, M., Jahan, S., Islam, M., Khan, T. and Saha, B., 2014. Nutritional evaluation and heavy metals content of selected tropical fruits in Bangladesh. International Food Research Journal 21: 609.
Sattar, A., Wahid, M. and Durrani, S.K., 1989. Concentration of selected heavy metals in spices, dry fruits and plant nuts. Plant Foods for Human Nutrition 39: 279–286. 10.1007/BF01091938
Scheinberg, I.H. and Sternlieb, I.J.T.A.j.o.c.n., 1996. Wilson disease and idiopathic copper toxicosis. The American journal of clinical nutrition 63: 842S–845S. 10.1093/ajcn/63.5.842
Shahsavani, A., Fakhri, Y., Ferrante, M., Keramati, H., Zandsalimi, Y., Bay, A., Hosseini Pouya, S.R., Moradi, B., Bahmani, Z. and Mousavi Khaneghah, A., 2017. Risk assessment of heavy metals bioaccumulation: fished shrimps from the Persian Gulf. Toxin Reviews 36: 322–330. 10.1080/15569543.2017.1312451
Shakya, P.R. and Khwaounjoo, N.M., 2013. Heavy metal contamination in green leafy vegetables collected from different market sites of Kathmandu and their associated health risks. Scientific World 11: 37–42. 10.3126/sw.v11i11.8550
Shi, W., Zhang, F., Zhang, X., Su, G., Wei, S., Liu, H., Cheng, S. and Yu, H., 2011. Identification of trace organic pollutants in freshwater sources in Eastern China and estimation of their associated human health risks. Ecotoxicology 20: 1099–1106. 10.1007/s10646-011-0671-8
Statista, 2013. Per capita consumption of fruit juice and nectar worldwide in 2012 and 2013, by country (in liters). Available at: https://www.statista.com/statistics/263205/per-capita-consumption-of-fruit-juice-worldwide-by-country/
Sudhakaran, M., Ramamoorthy, D., Savitha, V. and Balamurugan, S., 2018. Assessment of trace elements and its influence on physico-chemical and biological properties in coastal agroecosystem soil, Puducherry region. Geology, Ecology, and Landscapes 2: 169–176. 10.1080/24749508.2018.1452475
Sun, H., Brocato, J. and Costa, M., 2015. Oral chromium exposure and toxicity. Current Environmental Health Reports 2: 295–303. 10.1007/s40572-015-0054-z
Trumbo, P., Yates, A.A., Schlicker, S. and Poos, M., 2001. Dietary reference intakes: vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Journal of the Academy of Nutrition and Dietetics 101: 294.
USEPA, 2015. United state environmental protection agency. Quantitative Risk Assessment Calculations. Available at: https://www.epa.gov/sites/production/files/2015-05/documents/13.pdf
Varol, M., Sünbül, M.R., Aytop, H. and Yılmaz, C.H., 2020. Environmental, ecological and health risks of trace elements, and their sources in soils of Harran Plain, Turkey. Chemosphere 245: 125592. 10.1016/j.chemosphere.2019.125592
Wang, Q., Liu, J. and Cheng, S., 2015. Heavy metals in apple orchard soils and fruits and their health risks in Liaodong Peninsula, Northeast China. Environmental Monitoring and Assessment 187: 4178. 10.1007/s10661-014-4178-7
Wei, B. and Yang, L.J.M.J., 2010. A review of heavy metal contaminations in urban soils, urban road dusts and agricultural soils from China. Microchemical Journal 94: 99–107. 10.1016/j.microc.2009.09.014
WHO, 2001. World Health Organization. Iron deficiency anemia. assessment, prevention, and control. A guide for programme managers: pp. 47–62.
WHO, 2018. Word Health Organization (WHO). Healthy diet (2018). Available at: http://www.who.int/news-room/fact-sheets/detail/healthy-diet
Wilberforce, J.O., 2016. Review of metal uptake, plant-metal interaction and transport in plants in view of phytoremediation. IOSR Journals 9: 18–19.
Xu, L., Wang, T., Luo, W., Ni, K., Liu, S., Wang, L., Li, Q. and Lu, Y., 2013. Factors influencing the contents of metals and as in soils around the watershed of Guanting Reservoir, China. Journal of Environmental Sciences 25: 561–568. 10.1016/S1001-0742(12)60095-3
Zafarzadeh, A., Bay, A., Fakhri, Y., Keramati, H. and Hosseini Pouya, R., 2018. Heavy metal (Pb, Cu, Zn, and Cd) concentrations in the water and muscle of common carp (Cyprinus carpio) fish and associated non-carcinogenic risk assessment: Alagol wetland in the Golestan, Iran. Toxin Reviews 37: 154–160. 10.1080/15569543.2017.1386684
Zahoor, A., Jaffar, M., Saqib, M.J.N. and Science, F., 2003. Elemental distribution in summer fruits of Pakistan. Nutrition & Food Science 33: 203–207. 10.1108/00346650310499712