The role of fiber in gut health and chronic diseases a comprehensive review

Main Article Content

Sammra Maqsood
Matteo Bordiga
Baojun Xu

Keywords

Gut Microbiome; Gut-Brain axis; Dietary habits; Fiber-rich die

Abstract

The gut microbiota is vital for human health but contributes to various conditions ranging from inflammation to obesity if there is dysbiosis. Diets lacking in fiber contribute to gut health issues. Fiber acts as a prebiotic by feed-ing gut bacteria while encouraging microbial diversity. Decreased barrier functioning, resulting from low levels of fiber, has been linked to various gastrointestinal disorders. Through butyrate production, diets rich in fiber reduce the risk of chronic diseases, such as heart disease and type 2 diabetes. This review focuses on the role of dietary fiber in gut health and chronic diseases linked to the gut. Further, customized nutrition plans are followed as a way to upsurge fiber uptake to the extent based on lifestyle, genetics, and the composition of each person’s gut microbiome. Increasing fiber intake rendering to one’s requirements enhanced the benefits of improving gut health, reducing inflammation, and the prevention and treatment of chronic diseases, such as cancer, diabetes, and cardiovascular diseases.

Abstract 133 | PDF Downloads 101 XML Downloads 2 HTML Downloads 2

References

Adams, S., Che, D., Qin, G., Rui, H., Sello, C.T. and Hailong, J., 2018. Interactions of dietary fibre with nutritional components on gut microbial composition, function and health in monogastrics. Current Protein and Peptide Science 19(10): 1011–1023. https://doi.org/10.2174/1389203719666180508111843
Adeshirlarijaney, A. and Gewirtz, A.T., 2020. Considering gut microbiota in treatment of type 2 diabetes mellitus. Gut Microbes 11(3): 253–264. https://doi.org/10.1080/19490976.2020.1717719
Afzaal, M., Saeed, F., Shah, Y.A., Hussain, M., Rabail, R., Socol, C.T., Hassoun, A., Pateiro, M., Lorenzo, J.M., Rusu, A.V. and Aadil, R.M., 2022. Human gut microbiota in health and disease: unveiling the relationship. Frontiers in Microbiology 13: 999001. https://doi.org/10.3389/fmicb.2022.999001
Ali, S.R., Jordan, M., Nagarajan, P. and Amit, M., 2022. Nerve density and neuronal biomarkers in cancer. Cancers 14(19): 4817. https://doi.org/10.3390/cancers14194817
Amato, K.R., Arrieta, M.C., Azad, M.B., Bailey, M.T., Broussard, J.L., Bruggeling, C.E., Claud, E.C., Costello, E.K., Davenport, E.R., Dutilh, B.E., Swain Ewald, H.A., Ewald, P., Hanlon, E.C., Julion, W., Keshavarzian, A., Maurice, C.F., Miller, G.E., Preidis, G.A., Segurel, L., Singer, B., Subramanian, S., Zhao, L., and Kuzawa, C.W., 2021. The human gut microbiome and health inequities. Proceedings of the National Academy of Sciences 118(25): e2017947118. https://doi.org/10.1073/pnas.2017947118
Arikawa, A.Y., Samavat, H., Gross, M. and Kurzer, M.S., 2017. Plasma F2-isoprostanes are positively associated with glycemic load, but inversely associated with dietary polyunsaturated fatty acids and insoluble fiber in postmenopausal women. Journal of Nutrition 147(9): 1693–1699. https://doi.org/10.3945/jn.117.254631
Armstrong, H., Mander, I., Zhang, Z., Armstrong, D. and Wine, E., 2021. Not all fibers are born equal; variable response to dietary fiber subtypes in IBD. Frontiers in Pediatrics 8: 620189. https://doi.org/10.3389/fped.2020.620189
Baidoun, F., Elshiwy, K., Elkeraie, Y., Merjaneh, Z., Khoudari, G., Sarmini, M.T., Gad, M., Al-Husseini, M. and Saad, A., 2021. Colorectal cancer epidemiology: recent trends and impact on outcomes. Current Drug Targets 22(9): 998–1009. https://doi.org/10.2174/1389450121999201117115717
Bailén, M., Bressa, C., Martínez-López, S., González-Soltero, R., Montalvo Lominchar, M.G., San Juan, C. and Larrosa, M., 2020. Microbiota features associated with a high-fat/low-fiber diet in healthy adults. Frontiers in Nutrition 7: 583608. https://doi.org/10.3389/fnut.2020.583608
Baky, M.H., Salah, M., Ezzelarab, N., Shao, P., Elshahed, M.S. and Farag, M.A., 2024. Insoluble dietary fibers: structure, metabolism, interactions with human microbiome, and role in gut homeostasis. Critical Reviews in Food Science and Nutrition 64(7): 1954–1968. https://doi.org/10.1080/10408398.2022.2119931
Barkas, F., Nomikos, T., Liberopoulos, E. and Panagiotakos, D., 2020. Diet and cardiovascular disease risk among individuals with familial hypercholesterolemia: systematic review and meta-analysis. Nutrients 12(8): 2436. https://doi.org/10.3390/nu12082436
Barrett, E.M., Foster, S.I. and Beck, E.J., 2020. Whole grain and high-fibre grain foods: how do knowledge, perceptions and attitudes affect food choice? Appetite 149: 104630. https://doi.org/10.1016/j.appet.2020.104630
Basith, S., Manavalan, B., Shin, T.H., Park, C.B., Lee, W.S., Kim, J. and Lee, G., 2022. The impact of fine particulate matter 2.5 on the cardiovascular system: a review of the invisible killer. Nanomaterials 12(15): 2656. https://doi.org/10.3390/nano12152656
Basu, A., Feng, D., Planinic, P., Ebersole, J.L., Lyons, T.J. and Alexander, J.M., 2021. Dietary blueberry and soluble fiber supplementation reduces risk of gestational diabetes in women with obesity in a randomized controlled trial. Journal of Nutrition 151(5): 1128–1138. https://doi.org/10.1093/jn/nxaa435
Beller, L., Deboutte, W., Vieira-Silva, S., Falony, G., Tito, R.Y., Rymenans, L., Yinda, C.K., Vanmechelen, B., Van Espen, L., Janssen, D., Shi, C., Zeller, M., Maes, P., Faust, K., Van Ranst, M., Raes, J., and Matthijnssens, J., 2022. The virota and its transkingdom interactions in the healthy infant gut. Proceedings of the National Academy of Sciences 119(13): e2114619119. https://doi.org/10.1073/pnas.2114619119.
Beller, Z.W., Wesener, D.A., Seebeck, T.R., Guruge, J.L., Byrne, A.E., Henrissat, S., Terrapon, N., Henrissat, B., Rodionov, D.A., Osterman, A.L., Suarez, C., Bacalzo, N.P. Jr., Chen, Y., Couture, G., Lebrilla, C.B., Zhang, Z., Eastlund, E.R., McCann, C.H., Davis, G.D., and Gordon, J.I., 2023. Inducible CRISPR-targeted “knockdown” of human gut bacteroides in gnotobiotic mice discloses glycan utilization strategies. Proceedings of the National Academy of Sciences 120(39): e2311422120. https://doi.org/10.1073/pnas.2311422120.
Benítez-Páez, A., Del Pulgar, E.M.G., Kjølbæk, L., Brahe, L.K., Astrup, A., Larsen, L. and Sanz, Y., 2016. Impact of dietary fiber and fat on gut microbiota re-modeling and metabolic health. Trends in Food Science & Technology 57: 201–212. https://doi.org/10.1016/j.tifs.2016.11.001
Bishehsari, F., Engen, P.A., Preite, N.Z., Tuncil, Y.E., Naqib, A., Shaikh, M., Rossi, M., Wilber, S., Green, S.J., Hamaker, B.R. and Khazaie, K., 2018. Dietary fiber treatment corrects the composition of gut microbiota, promotes SCFA production, and suppresses colon carcinogenesis. Genes 9(2): 102. https://doi.org/10.3390/genes9020102
Bolm, L., Zghurskyi, P., Lapshyn, H., Petrova, E., Zemskov, S., Vashist, Y.K., Deichmann, S., Honselmann, K.C., Bronsert, P., Keck, T. and Wellner, U.F., 2020. Alignment of stroma fibers, microvessel density and immune cell populations determine overall survival in pancreatic cancer—an analysis of stromal morphology. PLoS One, 15(7): 0234568. https://doi.org/10.1371/journal.pone.0234568
Budden, K.F., Shukla, S.D., Bowerman, K.L., Vaughan, A., Gellatly, S.L., Wood, D.L., Lachner, N., Idrees, S., Rehman, S.F., Faiz, A. and Patel, V.K., 2024. Faecal microbial transfer and complex carbohydrates mediate protection against COPD. Gut 73(5): 751–769. https://doi.org/10.1136/gutjnl-2023-330521
Calatayud, M., Van den Abbeele, P., Ghyselinck, J., Marzorati, M., Rohs, E. and Birkett, A., 2021. Comparative effect of 22 dietary sources of fiber on gut microbiota of healthy humans in vitro. Frontiers in Nutrition 8: 700571. https://doi.org/10.3389/fnut.2021.700571
Camerotto, C., Cupisti, A., D’Alessandro, C., Muzio, F. and Gallieni, M., 2019. Dietary fiber and gut microbiota in renal diets. Nutrients 11(9): 2149. https://doi.org/10.3390/nu11092149
Cantero, I., Abete, I., Monreal, J.I., Martinez, J.A. and Zulet, M.A., 2017. Fruit fiber consumption specifically improves liver health status in obese subjects under energy restriction. Nutrients 9(7): 667. https://doi.org/10.3390/nu9070667
Capuano, E., 2017. The behavior of dietary fiber in the gastrointestinal tract determines its physiological effect. Critical Reviews in Food Science and Nutrition 57(16): 3543–3564. https://doi.org/10.1080/10408398.2016.1180501
Carlson, J.L., Erickson, J.M., Lloyd, B.B. and Slavin, J.L., 2018. Health effects and sources of prebiotic dietary fiber. Current Developments in Nutrition 2(3): nzy005. https://doi.org/10.1093/cdn/nzy005
Chakrabarti, A., Geurts, L., Hoyles, L., Iozzo, P., Kraneveld, A.D., La Fata, G., Miani, M., Patterson, E., Pot, B., Shortt, C. and Vauzour, D., 2022. The microbiota–gut–brain axis: pathways to better brain health. Perspectives on what we know, what we need to investigate and how to put knowledge into practice. Cellular and Molecular Life Sciences 79(2): 80. https://doi.org/10.1007/s00018-021-04060-w
Chang, H.W., McNulty, N.P., Hibberd, M.C., O’Donnell, D., Cheng, J., Lombard, V., Henrissat, B., Ilkayeva, O., Muehlbauer, M.J., Newgard, C.B., Barratt, M.J., Lin, X., Odle, J., and Gordon, J.I., 2021. Gut microbiome contributions to altered metabolism in a pig model of undernutrition. Proceedings of the National Academy of Sciences 118(21): e2024446118. https://doi.org/10.1073/pnas.2024446118.
Chen, J., Byun, H., Liu, R., Jung, I.-J., Pu, Q., Zhu, C.Y., Tanchoco, E., Alavi, S., Degnan, P.H., Madan, A.T., Roggiani, M., Beld, J., Goulian, M., Hsiao, A., and Zhu, J., 2022. A commensal-encoded genotoxin drives restriction of Vibrio cholerae colonization and host gut microbiome remodeling. Proceedings of the National Academy of Sciences 119(11): e2121180119.
Chen, J., Nouzova, M., Noriega, F.G., and Tatar, M., 2024. Gut-to-brain regulation of Drosophila aging through neuropeptide F, insulin, and juvenile hormone. Proceedings of the National Academy of Sciences 121(43): e2411987121. https://doi.org/10.1073/pnas.2411987121
Chen, Y., Wang, Z., Ding, J., Ming, D., Wang, W., Jiang, Z., Liu, L. and Wang, F., 2019. Effects of dietary fiber content and different fiber-rich ingredients on endogenous loss of fat and fatty acids in growing pigs. Journal of Animal Science and Biotechnology 10: 1–14. https://doi.org/10.1186/s40104-019-0348-3
Chi, M., 2023 CEd. Sheiladevi Sukumaran. Research progress of dietary fiber and its regulation of intestinal flora to improve type 2 diabetes mellitus. In: International Conference on Modern Medicine and Global Health (ICMMGH 2023), Oxford, Oxfordshire, UK. Vol. 12789; pp. 224–228. SPIE. https://doi.org/10.1117/12.2692594
Clemente-Suárez, V.J., Beltrán-Velasco, A.I., Redondo-Flórez, L., Martín-Rodríguez, A. and Tornero-Aguilera, J.F., 2023. Global impacts of western diet and its effects on metabolism and health: a narrative review. Nutrients 15(12): 2749. https://doi.org/10.3390/nu15122749
Clinton, S.K., Giovannucci, E.L. and Hursting, S.D., 2020. The world cancer research fund/American institute for cancer research third expert report on diet, nutrition, physical activity, and cancer: impact and future directions. Journal of Nutrition 150(4): 663–671. https://doi.org/10.1093/jn/nxz268
Cobo-López, S., Gupta, V.K., Sung, J., Guimerà, R. and Sales-Pardo, M., 2022. Stochastic block models reveal a robust nested pattern in healthy human gut microbiomes. Proceedings of the National Academy of Sciences of the United States of America (PNAS Nexus) 1(3): pgac055. https://doi.org/10.1093/pnasnexus/pgac055
Cui, J., Lian, Y., Zhao, C., Du, H., Han, Y., Gao, W., Xiao, H. and Zheng, J., 2019. Dietary fibers from fruits and vegetables and their health benefits via modulation of gut microbiota. Comprehensive Reviews in Food Science and Food Safety 18(5): 1514–1532. https://doi.org/10.1111/1541-4337.12489
Czarnowski, P., Bałabas, A., Kułaga, Z., Kulecka, M., Goryca, K., Pyśniak, K., Unrug-Bielawska, K., Kluska, A., Bagińska-Drabiuk, K., Głowienka-Stodolak, M. and Piątkowska, M., 2024. Effects of soluble dextrin fiber from potato starch on body weight and associated gut dysbiosis are evident in western diet-fed mice but not in overweight/obese children. Nutrients 16(7): 917. https://doi.org/10.3390/nu16070917
Dai, F.J. and Chau, C.F., 2017. Classification and regulatory perspectives of dietary fiber. Journal of Food and Drug Analysis 25(1): 37–42. https://doi.org/10.1016/j.jfda.2016.09.006
Davey, M., Puelz, C., Rossi, S., Smith, M.A., Wells, D.R., Sturgeon, G.M., Segars, W.P., Vavalle, J.P., Peskin, C.S. and Griffith, B.E., 2024. Simulating cardiac fluid dynamics in the human heart. Proceedings of the National Academy of Sciences of the United States of America (PNAS Nexus) 3(10): 392. https://doi.org/10.1093/pnasnexus/pgae392
Debnath, S., Jawahar, S., Muntaj, H., Purushotham, V., Sharmila, G., Sireesha, K. and Babu, M.N., 2019. A review on dietary fiber and its application. Research Journal of Pharmacognosy and Phytochemistry 11(3): 109–113. http://dx.doi.org/10.5958/0975-4385.2019.00019.0
Delannoy-Bruno, O., Desai, C., Castillo, J.J., Couture, G., Barve, R.A., Lombard, V., Henrissat, B., Cheng, J., Han, N., Hayashi, D.K., Meynier, A., Vinoy, S., Lebrilla, C.B., Marion, S., Heath, A.C., Barratt, M.J., and Gordon, J.I., 2022. An approach for evaluating the effects of dietary fiber polysaccharides on the human gut microbiome and plasma proteome. Proceedings of the National Academy of Sciences 119(20): e2123411119. https://doi.org/10.1073/pnas.2123411119
Delzenne, N.M., Olivares, M., Neyrinck, A.M., Beaumont, M., Kjølbæk, L., Larsen, T.M., Benítez-Páez, A., Romaní-Pérez, M., Garcia-Campayo, V., Bosscher, D. and Sanz, Y., 2020. Nutritional interest of dietary fiber and prebiotics in obesity: lessons from the MyNewGut consortium. Clinical Nutrition 39(2): 414–424. https://doi.org/10.1016/j.clnu.2019.03.002
De Roos, B. and Brennan, L., 2017. Personalised interventions—a precision approach for the next generation of dietary intervention studies. Nutrients 9(8): 847. https://doi.org/10.3390/nu9080847
Dimidi, E., Christodoulides, S., Scott, S.M. and Whelan, K., 2017. Mechanisms of action of probiotics and the gastrointestinal microbiota on gut motility and constipation. Advances in Nutrition 8(3): 484–494. https://doi.org/10.3945/an.116.014407
Dinan, T.G. and Cryan, J.F., 2017. The microbiome-gut-brain axis in health and disease. Gastroenterology Clinics 46(1): 77–89. https://doi.org/10.1016/j.gtc.2016.09.007
Dong, Y., Chen, L., Gutin, B. and Zhu, H., 2019. Total, insoluble, and soluble dietary fiber intake and insulin resistance and blood pressure in adolescents. European Journal of Clinical Nutrition 73(8): 1172–1178. https://doi.org/10.1038/s41430-018-0372-y
Donovan, S.M., 2017. Introduction to the special focus issue on the impact of diet on gut microbiota composition and function and future opportunities for nutritional modulation of the gut microbiome to improve human health. Gut Microbes 8(2): 75–81. https://doi.org/10.1080/19490976.2017.1299309
Doroudi, M., Schoen, R.E. and Pinsky, P.F., 2017. Early detection versus primary prevention in the PLCO flexible sigmoidoscopy screening trial: which has the greatest impact on mortality?. Cancer 123(24): 4815–4822. https://doi.org/10.1002/cncr.31034
Dreher, M.L., 2018. Whole fruits and fruit fiber emerging health effects. Nutrients 10(12): 1833. https://doi.org/10.3390/nu10121833
Duque, A., Mediano, M.F.F., De Lorenzo, A. and Rodrigues Jr, L.F., 2021. Cardiovascular autonomic neuropathy in diabetes: pathophysiology, clinical assessment and implications. World Journal of Diabetes 12(6): 855. https://doi.org/10.4239/wjd.v12.i6.855
Emilien, C.H., Hsu, W.H., and Hollis, J.H., 2020. The effect of soluble fiber dextrin on subjective and physiological markers of appetite: a randomized trial. Nutrients 12(11): 3341. https://doi.org/10.3390/nu12113341
Eriksen, A.K., Brunius, C., Mazidi, M., Hellström, P.M., Risérus, U., Iversen, K.N., Fristedt, R., Sun, L., Huang, Y., Nørskov, N.P. and Knudsen, K.E.B., 2020. Effects of whole-grain wheat, rye, and lignan supplementation on cardiometabolic risk factors in men with metabolic syndrome: a randomized crossover trial. American Journal of Clinical Nutrition 111(4): 864–876. https://doi.org/10.1093/ajcn/nqaa026
Esteban, R.M., Mollá, E. and Benítez, V. 2017. Soucres of fiber. In: Rodney A. Samaan (Ed.) Dietary Fiber for the Prevention of Cardiovascular Disease. Academic Press, New York, NY, Chap. 7, pp. 121–146. https://doi.org/10.1016/B978-0-12-805130-6.00007-0
Fachi, J.L., Di Luccia, B., Gilfillan, S., Chang, H.W., Song, C., Cheng, J., Cella, M., Vinolo, M.A., Gordon, J.I., and Colonna, M., 2024. Deficiency of IL-22–binding protein enhances the ability of the gut microbiota to protect against enteric pathogens. Proceedings of the National Academy of Sciences 121(19): e2321836121. https://doi.org/10.1073/pnas.2321836121
Feng, L., Raman, A.S., Hibberd, M.C., Cheng, J., Griffin, N.W., Peng, Y., Leyn, S.A., Rodionov, D.A., Osterman, A.L., and Gordon, J.I., 2020. Identifying determinants of bacterial fitness in a model of human gut microbial succession. Proceedings of the National Academy of Sciences 117(5): 2622–2633. https://doi.org/10.1073/pnas.1918951117
Fu, T., Li, Y., Oh, T.G., Cayabyab, F., He, N., Tang, Q., Coulter, S., Truitt, M., Medina, P., He, M., Yu, R.T., Atkins, A., Zheng, Y., Liddle, C., Downes, M., and Evans, R.M., 2022. FXR mediates ILC-intrinsic responses to intestinal inflammation. Proceedings of the National Academy of Sciences 119(51): e2213041119. https://doi.org/10.1073/pnas.2213041119
Fu, J., Zheng, Y., Gao, Y. and Xu, W., 2022a. Dietary fiber intake and gut microbiota in human health. Microorganisms 10(12): 2507. https://doi.org/10.3390/microorganisms10122507
Fuller, S., Beck, E., Salman, H. and Tapsell, L., 2016. New horizons for the study of dietary fiber and health: a review. Plant Foods for Human Nutrition 71: 1–12. https://doi.org/10.1007/s11130-016-0529-6
Fu-Shin, X.Y., Lee, P.S., Yang, L., Gao, N., Zhang, Y., Ljubimov, A.V., Yang, E., Zhou, Q. and Xie, L., 2022. The impact of sensory neuropathy and inflammation on epithelial wound healing in diabetic corneas. Progress in Retinal and Eye Research 89: 101039. https://doi.org/10.1016/j.preteyeres.2021.101039
Gao, X., Cao, Q., Cheng, Y., Zhao, D., Wang, Z., Yang, H., Wu, Q., You, L., Wang, Y., Lin, Y., Li, X., Wang, Y., Bian, J.-S., Sun, D., Kong, L., Birnbaumer, L., and Yang, Y., 2018. Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response. Proceedings of the National Academy of Sciences 115(13): E2960–E2969. https://doi.org/10.1073/pnas.1720696115
Garutti, M., Nevola, G., Mazzeo, R., Cucciniello, L., Totaro, F., Bertuzzi, C.A., Caccialanza, R., Pedrazzoli, P. and Puglisi, F., 2022. The impact of cereal grain composition on the health and disease outcomes. Frontiers in Nutrition 9: 888974. https://doi.org/10.3389/fnut.2022.888974
Geng, J., Ji, B., Li, G., López-Isunza, F., and Nielsen, J., 2021. CODY enables quantitatively spatiotemporal predictions on in vivo gut microbial variability induced by diet intervention. Proceedings of the National Academy of Sciences 118(13): e2019336118. https://doi.org/10.1073/pnas.2019336118
Gill, S.K., Rossi, M., Bajka, B. and Whelan, K., 2021. Dietary fibre in gastrointestinal health and disease. Nature Reviews Gastroenterology & Hepatology 18(2): 101–116. https://doi.org/10.1038/s41575-020-00375-4
Gomaa, E.Z., 2020. Human gut microbiota/microbiome in health and diseases: a review. Antonie Van Leeuwenhoek 113(12): 2019–2040. https://doi.org/10.1007/s10482-020-01474-7
Goyal, M.S., Venkatesh, S., Milbrandt, J., Gordon, J.I., and Raichle, M.E., 2015. Feeding the brain and nurturing the mind: linking nutrition and the gut microbiota to brain development. Proceedings of the National Academy of Sciences 112(46): 14105–14112. https://doi.org/10.1073/pnas.1511465112
Guan, Z.W., Yu, E.Z. and Feng, Q., 2021. Soluble dietary fiber, one of the most important nutrients for the gut microbiota. Molecules 26(22): 6802. https://doi.org/10.3390/molecules26226802
Han, X., Ma, Y., Ding, S., Fang, J. and Liu, G., 2023. Regulation of dietary fiber on intestinal microorganisms and its effects on animal health. Animal Nutrition 14: 356–369. https://doi.org/10.1016/j.aninu.2023.06.004
He, Y., Wang, B., Wen, L., Wang, F., Yu, H., Chen, D., Su, X. and Zhang, C., 2022. Effects of dietary fiber on human health. Food Science and Human Wellness 11(1): 1–10. https://doi.org/10.1016/j.fshw.2021.07.001
Herrick, L.P., Goh, J., Menke, W., Campbell, M.S., Fleenor, B.S., Abel, M.G. and Bergstrom, H.C., 2020. Effects of curcumin and fenugreek soluble fiber on the physical working capacity at the fatigue threshold, peak oxygen consumption, and time to exhaustion. Journal of Strength & Conditioning Research 34(12): 3346–3355. https://doi.org/10.1519/jsc.0000000000003852
Hiel, S., Bindels, L.B., Pachikian, B.D., Kalala, G., Broers, V., Zamariola, G., Chang, B.P., Kambashi, B., Rodriguez, J., Cani, P.D. and Neyrinck, A.M., 2019. Effects of a diet based on inulin-rich vegetables on gut health and nutritional behavior in healthy humans. American Journal of Clinical Nutrition 109(6): 1683–1695. https://doi.org/10.1093/ajcn/nqz001
Hills, R.D., Pontefract, B.A., Mishcon, H.R., Black, C.A., Sutton, S.C. and Theberge, C.R., 2019. Gut microbiome: profound implications for diet and disease. Nutrients 11(7): 1613. https://doi.org/10.3390/nu11071613
Holingue, C., Budavari, A.C., Rodriguez, K.M., Zisman, C.R., Windheim, G. and Fallin, M.D., 2020. Sex differences in the gut-brain axis: implications for mental health. Current Psychiatry Reports 22: 1–11. https://doi.org/10.1007/s11920-020-01202-y
Holscher, H.D., 2017. Dietary fiber and prebiotics and the gastrointestinal microbiota. Gut Microbes 8(2): 172–184. https://doi.org/10.1080/19490976.2017.1290756
Hopek, S. and Siniak, G., 2020. Diabetic neuropathy: new perspectives on early diagnosis and treatments. Journal of Current Diabetes Reports 1(01): 12–14.
Hullings, A.G., Sinha, R., Liao, L.M., Freedman, N.D., Graubard, B.I. and Loftfield, E., 2020. Whole grain and dietary fiber intake and risk of colorectal cancer in the NIH-AARP Diet and Health Study cohort. American Journal of Clinical Nutrition 112(3): 603–612. https://doi.org/10.1093/ajcn/nqaa161
Hussain, S., Jõudu, I. and Bhat, R., 2020. Dietary fiber from underutilized plant resources—a positive approach for valorization of fruit and vegetable wastes. Sustainability 12(13): 5401. https://doi.org/10.3390/su12135401
Ioniță-Mîndrican, C.B., Ziani, K., Mititelu, M., Oprea, E., Neacșu, S.M., Moroșan, E., Dumitrescu, D.E., Roșca, A.C., Drăgănescu, D. and Negrei, C., 2022. Therapeutic benefits and dietary restrictions of fiber intake: a state of the art review. Nutrients 14(13): 2641. https://doi.org/10.3390/nu14132641
Ismael, S., Silvestre, M.P., Vasques, M., Araújo, J.R., Morais, J., Duarte, M.I., Pestana, D., Faria, A., Pereira-Leal, J.B., Vaz, J. and Ribeiro, P., 2021. A pilot study on the metabolic impact of Mediterranean diet in type 2 diabetes: is gut microbiota the key?. Nutrients 13(4): 1228. https://doi.org/10.3390/nu13041228
Iversen, K.N., Dicksved, J., Zoki, C., Fristedt, R., Pelve, E.A., Langton, M. and Landberg, R., 2022. The effects of high fiber rye, compared to refined wheat, on gut microbiota composition, plasma short chain fatty acids, and implications for weight loss and metabolic risk factors (the RyeWeight Study). Nutrients 14(8): 1669. https://doi.org/10.3390/nu14081669
Jakeman, S.A., Henry, C.N., Martin, B.R., McCabe, G.P., McCabe, L.D., Jackson, G.S., Peacock, M. and Weaver, C.M., 2016. Soluble corn fiber increases bone calcium retention in postmenopausal women in a dose-dependent manner: a randomized crossover trial. American Journal of Clinical Nutrition 104(3): 837–843. https://doi.org/10.3945/ajcn.116.132761
Jha, R., Fouhse, J.M., Tiwari, U.P., Li, L. and Willing, B.P., 2019. Dietary fiber and intestinal health of monogastric animals. Frontiers in Veterinary Science 6: 48. https://doi.org/10.3389/fvets.2019.00048
Jha, R. and Mishra, P., 2021. Dietary fiber in poultry nutrition and their effects on nutrient utilization, performance, gut health, and on the environment: a review. Journal of Animal Science and Biotechnology 12: 1–16. https://doi.org/10.1186/s40104-021-00576-0
Jinnette, R., Narita, A., Manning, B., McNaughton, S.A., Mathers, J.C. and Livingstone, K.M., 2021. Does personalized nutrition advice improve dietary intake in healthy adults? A systematic review of randomized controlled trials. Advances in Nutrition 12(3): 657–669. https://doi.org/10.1093/advances/nmaa144
Jovanovski, E., Komishon, A., Au-Yeung, F., Zurbau, A., Jenkins, A.L., Sung, M.K., Josse, R. and Vuksan, V., 2020. Vascular effects of combined enriched Korean Red ginseng (Panax Ginseng) and American ginseng (Panax Quinquefolius) administration in individuals with hypertension and type 2 diabetes: a randomized controlled trial. Complementary Therapies in Medicine 49: 102338. https://doi.org/10.1016/j.ctim.2020.102338
Jovanovski, E., Mazhar, N., Komishon, A., Khayyat, R., Li, D., Blanco Mejia, S., Khan, T., Jenkins, A.L., Smircic-Duvnjak, L., Sievenpiper, J.L. and Vuksan, V., 2021. Effect of viscous fiber supplementation on obesity indicators in individuals consuming calorie-restricted diets: a systematic review and meta-analysis of randomized controlled trials. European Journal of Nutrition 60: 101–112. https://doi.org/10.1007/s00394-020-02224-1
Joye, I.J., 2020. Dietary fibre from whole grains and their benefits on metabolic health. Nutrients 12(10): 3045. https://doi.org/10.3390/nu12103045
Katsirma, Z., Dimidi, E., Rodriguez-Mateos, A. and Whelan, K., 2021. Fruits and their impact on the gut microbiota, gut motility and constipation. Food & Function 12(19): 8850–8866. https://doi.org/10.1039/D1FO01125A
Kaye, D.M., Shihata, W.A., Jama, H.A., Tsyganov, K., Ziemann, M., Kiriazis, H., Horlock, D., Vijay, A., Giam, B., Vinh, A. and Johnson, C., 2020. Deficiency of prebiotic fiber and insufficient signaling through gut metabolite-sensing receptors leads to cardiovascular disease. Circulation 141(17): 1393–1403. https://doi.org/10.1161/CIRCULATIONAHA.119.043081
Khan, K., Jovanovski, E., Ho, H.V.T., Marques, A.C.R., Zurbau, A., Mejia, S.B., Sievenpiper, J.L. and Vuksan, V., 2018. The effect of viscous soluble fiber on blood pressure: a systematic review and meta-analysis of randomized controlled trials. Nutrition, Metabolism and Cardiovascular Diseases 28(1): 3–13. https://doi.org/10.1016/j.numecd.2017.09.007
Kirthi, V., Perumbalath, A., Brown, E., Nevitt, S., Petropoulos, I.N., Burgess, J., Roylance, R., Cuthbertson, D.J., Jackson, T.L., Malik, R.A. and Alam, U., 2021. Prevalence of peripheral neuropathy in pre-diabetes: a systematic review. BMJ Open Diabetes Research and Care 9(1): e002040. https://doi.org/10.1136/bmjdrc-2020-002040
Klinder, A., Shen, Q., Heppel, S., Lovegrove, J.A., Rowland, I. and Tuohy, K.M., 2016. Impact of increasing fruit and vegetables and flavonoid intake on the human gut microbiota. Food & Function 7(4): 1788–1796. https://doi.org/10.1039/c5fo01096a
Koh, A., De Vadder, F., Kovatcheva-Datchary, P. and Bäckhed, F., 2016. From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites. Cell 165(6): 1332–1345. https://doi.org/10.1016/j.cell.2016.05.041
Korcz, E., Kerényi, Z. and Varga, L., 2018. Dietary fibers, prebiotics, and exopolysaccharides produced by lactic acid bacteria: potential health benefits with special regard to cholesterol-lowering effects. Food & Function 9(6): 3057–3068. https://doi.org/10.1039/C8FO00118A
Korczak, R. and Slavin, J.L., 2020. Definitions, regulations, and new frontiers for dietary fiber and whole grains. Nutrition Reviews 78(Supplement 1): 6–12. https://doi.org/10.1093/nutrit/nuz061
Kranz, S., Dodd, K.W., Juan, W.Y., Johnson, L.K. and Jahns, L., 2017. Whole grains contribute only a small proportion of dietary fiber to the US diet. Nutrients 9(2): 153. https://doi.org/10.3390/nu9020153
Kudou, K., Kimura, K., Tsutsumi, R., Hashimoto, N., Wada, H. and Ikeda, T., 2022. Use of insoluble dietary fiber and probiotics for bowel preparation before colonoscopy: a prospective study. Surgical Laparoscopy Endoscopy & Percutaneous Techniques 32(2): 153–158. https://doi.org/10.1097/sle.0000000000000995
Kumar, J., Rani, K. and Datt, C., 2020. Molecular link between dietary fibre, gut microbiota and health. Molecular Biology Reports 47(8): 6229–6237. https://doi.org/10.1007/s11033-020-05611-3
Laranjeiro, R., Harinath, G., Hewitt, J.E., Hartman, J.H., Royal, M.A., Meyer, J.N., Vanapalli, S.A., and Driscoll, M., 2019. Swim exercise in Caenorhabditis elegans extends neuromuscular and gut healthspan, enhances learning ability, and protects against neurodegeneration. Proceedings of the National Academy of Sciences 116(47): 23829–23839. https://doi.org/10.1073/pnas.1909210116

La Torre, D., Verbeke, K. and Dalile, B., 2021. Dietary fibre and the gut–brain axis: microbiota-dependent and independent mechanisms of action. Gut Microbiome 2: e3. https://doi.org/10.1017/gmb.2021.3
Lamothe, L.M., Cantu-Jungles, T.M., Chen, T., Green, S., Naqib, A., Srichuwong, S. and Hamaker, B.R., 2021. Boosting the value of insoluble dietary fiber to increase gut fermentability through food processing. Food & Function, 12(21): 10658-–10666. https://doi.org/10.1039/D1FO02146J
Lee, Y. and Kim, Y.K., 2021. Understanding the connection between the gut–brain axis and stress/anxiety disorders. Current Psychiatry Reports 23: 1–7. https://doi.org/10.1007/s11920-021-01235-x
Lee, J., Wellenstein, K., Rahnavard, A., Nelson, A.T., Holter, M.M., Cummings, B.P., Yeliseyev, V., Castoldi, A., Clish, C.B., Bry, L., Siegel, D., and Kahn, B.B., 2024. Beneficial metabolic effects of PAHSAs depend on the gut microbiota in diet-induced obese mice but not in chow-fed mice. Proceedings of the National Academy of Sciences 121(28): e2318691121. https://doi.org/10.1073/pnas.2318691121
Li, Y., Han, M., Song, J., Liu, S., Wang, Y., Su, X., Wei, K., Xu, Z., Li, H. and Wang, Z., 2022. The prebiotic effects of soluble dietary fiber mixture on renal anemia and the gut microbiota in end-stage renal disease patients on maintenance hemodialysis: a prospective, randomized, placebo-controlled study. Journal of Translational Medicine 20(1): 599. https://doi.org/10.1186/s12967-022-03812-x
Li, Y., Kang, Y., Du, Y., Chen, M., Guo, L., Huang, X., Li, T., Chen, S., Yang, F., Yu, F. and Hong, J., 2022. Effects of Konjaku flour on the gut microbiota of obese patients. Frontiers in Cellular and Infection Microbiology 12: 771748. https://doi.org/10.3389/fcimb.2022.771748
Li, W.Z., Stirling, K., Yang, J.J. and Zhang, L., 2020. Gut microbiota and diabetes: from correlation to causality and mechanism. World Journal of Diabetes 11(7): 293. https://doi.org/10.4239/wjd.v11.i7.293
Liang, S., Wu, X. and Jin, F., 2018. Gut-brain psychology: rethinking psychology from the microbiota–gut–brain axis. Frontiers in Integrative Neuroscience 12: 33. https://doi.org/10.3389/fnint.2018.00033
Lin, A.Z., Fu, X., Jiang, Q., Zhou, X., Hwang, S.H., Yin, H.H., Ni, K.D., Pan, Q.J., He, X., Zhang, L.T., Meng, Y.W., Liu, Y.N., Hammock, B.D., and Liu, J.Y., 2024. Metabolomics reveals soluble epoxide hydrolase as a therapeutic target for high-sucrose diet-mediated gut barrier dysfunction. Proceedings of the National Academy of Sciences 121(48): e2409841121. https://doi.org/10.1073/pnas.2409841121
Liu, H., Zhang, M., Ma, Q., Tian, B., Nie, C., Chen, Z. and Li, J., 2020. Health beneficial effects of resistant starch on diabetes and obesity via regulation of gut microbiota: a review. Food & Function 11(7): 5749–5767. https://doi.org/10.1039/D0FO00855A
Loo, Y.T., Howell, K., Chan, M., Zhang, P. and Ng, K., 2020. Modulation of the human gut microbiota by phenolics and phenolic fiber-rich foods. Comprehensive Reviews in Food Science and Food Safety 19(4): 1268–1298. https://doi.org/10.1111/1541-4337.12563
Makki, K., Deehan, E.C., Walter, J. and Bäckhed, F., 2018. The impact of dietary fiber on gut microbiota in host health and disease. Cell Host & Microbe 23(6): 705–715. https://doi.org/10.1016/j.chom.2018.05.012
Malipatlolla, D.K., Devarakonda, S., Patel, P., Sjöberg, F., Rascón, A., Grandér, R., Skokic, V., Kalm, M., Danial, J., Mehdin, E. and Warholm, M., 2021. A fiber-rich diet and radiation-induced injury in the murine intestinal mucosa. International Journal of Molecular Sciences 23(1): 439. https://doi.org/10.3390/ijms23010439
Manrique, P., Bolduc, B., Walk, S.T., van der Oost, J., de Vos, W.M., and Young, M.J., 2016. Healthy human gut phageome. Proceedings of the National Academy of Sciences 113(37): 10400–10405. https://doi.org/10.1073/pnas.1601060113
Mao, T., Huang, F., Zhu, X., Wei, D. and Chen, L., 2021. Effects of dietary fiber on glycemic control and insulin sensitivity in patients with type 2 diabetes: a systematic review and meta-analysis. Journal of Functional Foods 82: 104500. https://doi.org/10.1016/j.jff.2021.104500
Mark Welch, J.L., Hasegawa, Y., McNulty, N.P., Gordon, J.I., and Borisy, G.G., 2017. Spatial organization of a model 15-member human gut microbiota established in gnotobiotic mice. Proceedings of the National Academy of Sciences 114(43): E9105–E9114. https://doi.org/10.1073/pnas.1711596114
Martel, J., Chang, S.H., Ko, Y.F., Hwang, T.L., Young, J.D. and Ojcius, D.M., 2022. Gut barrier disruption and chronic disease. Trends in Endocrinology & Metabolism 33(4): 247–265. https://doi.org/10.1016/j.tem.2022.01.002
Martin-Gallausiaux, C., Marinelli, L., Blottière, H.M., Larraufie, P. and Lapaque, N., 2021. SCFA: mechanisms and functional importance in the gut. Proceedings of the Nutrition Society 80(1): 37–49. https://doi.org/10.1017/S0029665120006916
Matt, S.M., Allen, J.M., Lawson, M.A., Mailing, L.J., Woods, J.A. and Johnson, R.W., 2018. Butyrate and dietary soluble fiber improve neuroinflammation associated with aging in mice. Frontiers in Immunology 9: 1832. https://doi.org/10.3389/fimmu.2018.01832
Mayrhofer, G., 2019. Physiology of the Intestinal Immune System. In: Newby, Timothy J. and Stokes, Christopher R. (Eds.) Local Immune Responses of Gut. CRC Press, Boca Raton, FL, Chap. 1. pp. 1–96. https://doi.org/10.1201/9780429279508
McRorie Jr, J.W. and McKeown, N.M., 2017. Understanding the physics of functional fibers in the gastrointestinal tract: an evidence-based approach to resolving enduring misconceptions about insoluble and soluble fiber. Journal of the Academy of Nutrition and Dietetics 117(2): 251–264. https://doi.org/10.1016/j.jand.2016.09.021
Meldrum, O.W., and Yakubov, G.E. (2024). Journey of dietary fiber along the gastrointestinal tract: role of physical interactions, mucus, and biochemical transformations. Critical Reviews in Food Science and Nutrition 1–29. https://doi.org/10.1080/10408398.2024.2390556
Merenkova, S.P., Zinina, O.V., Stuart, M., Okuskhanova, E.K. and Androsova, N.V., 2020. Effects of dietary fiber on human health: a review. Human Sport Medicine 20(1): 106–113. https://doi.org/10.14529/hsm200113
Miao, T., Zhang, X., Zhang, C., Wu, J., Zhu, Y., Xiao, M., Zhang, N., Zhong, Y., Liu, Y., Lin, Y. and Wu, Y., 2024. Type 3 resistant starch from canna edulis reduce lipid levels in patients with mild hyperlipidemia through altering gut microbiome: a double-blind randomized controlled trial. Pharmacological Research 107232. https://doi.org/10.1016/j.phrs.2024.107232
Miles, F.L., Navarro, S.L., Schwarz, Y., Gu, H., Djukovic, D., Randolph, T.W., Shojaie, A., Kratz, M., Hullar, M.A., Lampe, P.D. and Neuhouser, M.L., 2017. Plasma metabolite abundances are associated with urinary enterolactone excretion in healthy participants on controlled diets. Food & Function 8(9): 3209–3218. https://doi.org/10.1039/c7fo00684e
Miller, K.B., 2020. Review of whole grain and dietary fiber recommendations and intake levels in different countries. Nutrition Reviews 78(Supplement 1): 29–36. https://doi.org/10.1093/nutrit/nuz052
Miranda-Galvis, M., Loveless, R., Kowalski, L.P. and Teng, Y., 2021. Impacts of environmental factors on head and neck cancer pathogenesis and progression. Cells 10(2): 389. https://doi.org/10.3390/cells10020389
Mirzaei, R., Afaghi, A., Babakhani, S., Sohrabi, M.R., Hosseini-Fard, S.R., Babolhavaeji, K., Akbari, S.K.A., Yousefimashouf, R. and Karampoor, S., 2021. Role of microbiota-derived short-chain fatty acids in cancer development and prevention. Biomedicine & Pharmacotherapy 139: 111619. https://doi.org/10.1016/j.biopha.2021.111619
Molina-Montes, E., Salamanca-Fernández, E., Garcia-Villanova, B. and Sánchez, M.J., 2020. The impact of plant-based dietary patterns on cancer-related outcomes: a rapid review and meta-analysis. Nutrients 12(7): 2010. https://doi.org/10.3390/nu12072010
Moore, J.B., 2020. From personalised nutrition to precision medicine: the rise of consumer genomics and digital health. Proceedings of the Nutrition Society 79(3): 300–310. https://doi.org/10.1017/S0029665120006977
Moreira, F.D., Mendes, G.F., Nascimento, G.D., Reis, C.E., Gallassi, A.D. and Welker, A.F., 2024. Postprandial hyperglycemia in patients with type 2 diabetes is reduced by raw insoluble fiber: a randomized trial. Nutrition, Metabolism and Cardiovascular Diseases 34(12): 2673–2679. https://doi.org/10.1016/j.numecd.2023.09.013
Mörkl, S., Wagner-Skacel, J., Lahousen, T., Lackner, S., Holasek, S.J., Bengesser, S.A., Painold, A., Holl, A.K. and Reininghaus, E., 2020. The role of nutrition and the gut-brain axis in psychiatry: a review of the literature. Neuropsychobiology 79(1): 80–88. https://doi.org/10.1159/000492834
Morrison, K.E., Jašarević, E., Howard, C.D. and Bale, T.L., 2020. It's the fiber, not the fat: significant effects of dietary challenge on the gut microbiome. Microbiome 8: 1–11. https://doi.org/10.1186/s40168-020-0791-6
Nie, Q., Hu, J., Gao, H., Li, M., Sun, Y., Chen, H., Zuo, S., Fang, Q., Huang, X., Yin, J. and Nie, S., 2021. Bioactive dietary fibers selectively promote gut microbiota to exert antidiabetic effects. Journal of Agricultural and Food Chemistry 69(25): 7000–7015. https://doi.org/10.1021/acs.jafc.1c01465
Nolte Fong, J.V., Miketinas, D., Moore, L.W., Nguyen, D.T., Graviss, E.A., Ajami, N. and Patterson, M.A., 2022. Precision nutrition model predicts glucose control of overweight females following the consumption of potatoes high in resistant starch. Nutrients 14(2): 268. https://doi.org/10.3390/nu14020268
Ojo, O., Feng, Q.Q., Ojo, O.O. and Wang, X.H., 2020. The role of dietary fibre in modulating gut microbiota dysbiosis in patients with type 2 diabetes: a systematic review and meta-analysis of randomised controlled trials. Nutrients 12(11): 3239. https://doi.org/10.3390/nu12113239
Ortega-Santos, C.P. and Whisner, C.M., 2019. The key to successful weight loss on a high-fiber diet may be in gut microbiome Prevotella abundance. Journal of Nutrition 149(12): 2083–2084. https://doi.org/10.1093/jn/nxz248
Osborn, L.J., Schultz, K., Massey, W., DeLucia, B., Choucair, I., Varadharajan, V., ... and Claesen, J., 2022. A gut microbial metabolite of dietary polyphenols reverses obesity-driven hepatic steatosis. Proceedings of the National Academy of Sciences 119(48): e2202934119. https://doi.org/10.1073/pnas.2202934119
Oyarzun, J.P., Kuntz, T.M., Stussi, Y., Karaman, O.T., Vranos, S., Callaghan, B.L., Huttenhower, C., LeDoux, J.E., and Phelps, E.A., 2022. Human threat learning is associated with gut microbiota composition. Proceedings Of The National Academy Of Sciences Of The United States Of America PNAS Nexus 1(5): pgac271. https://doi.org/10.1093/pnasnexus/pgac271
Papakonstantinou, E., Xaidara, M., Siopi, V., Giannoglou, M., Katsaros, G., Theodorou, G., Maratou, E., Poulia, K.A., Dimitriadis, G.D. and Skandamis, P.N., 2022. Effects of spaghetti differing in soluble fiber and protein content on glycemic responses in humans: a randomized clinical trial in healthy subjects. International Journal of Environmental Research and Public Health 19(5): 3001. https://doi.org/10.3390/ijerph19053001
Partula, V., Deschasaux, M., Druesne-Pecollo, N., Latino-Martel, P., Desmetz, E., Chazelas, E., Kesse-Guyot, E., Julia, C., Fezeu, L.K., Galan, P. and Hercberg, S., 2020. Associations between consumption of dietary fibers and the risk of cardiovascular diseases, cancers, type 2 diabetes, and mortality in the prospective NutriNet-Santé cohort. American Journal of Clinical Nutrition 112(1): 195–207. https://doi.org/10.1093/ajcn/nqaa063
Peredo-Lovillo, A., Romero-Luna, H.E. and Jiménez-Fernández, M., 2020. Health promoting microbial metabolites produced by gut microbiota after prebiotics metabolism. Food Research International 136: 109473. https://doi.org/10.1016/j.foodres.2020.109473
Perler, B.K., Friedman, E.S. and Wu, G.D., 2023. The role of the gut microbiota in the relationship between diet and human health. Annual Review of Physiology 85(1): 449–468. https://doi.org/10.1146/annurev-physiol-031522-092054
Portincasa, P., Bonfrate, L., Vacca, M., De Angelis, M., Farella, I., Lanza, E., Khalil, M., Wang, D.Q.H., Sperandio, M. and Di Ciaula, A., 2022. Gut microbiota and short chain fatty acids: implications in glucose homeostasis. International Journal of Molecular Sciences 23(3): 1105. https://doi.org/10.3390/ijms23031105
Prasad, K.N. and Bondy, S.C., 2019. Dietary fibers and their fermented short-chain fatty acids in prevention of human diseases. Bioactive Carbohydrates and Dietary Fibre 17: 100170. https://doi.org/10.1016/j.bcdf.2018.09.001
Provensi, G., Schmidt, S.D., Boehme, M., Bastiaanssen, T.F.S., Rani, B., Costa, A., Busca, K., Fouhy, F., Strain, C., Stanton, C., Blandina, P., Izquierdo, I., Cryan, J.F., and Passani, M.B., 2019. Preventing adolescent stress-induced cognitive and microbiome changes by diet. Proceedings of the National Academy of Sciences 116(19): 9644–9651. https://doi.org/10.1073/pnas.1820832116
Querdasi, F.R., Enders, C., Karnani, N., Broekman, B., Yap Seng, C., Gluckman, P.D., Daniele, L.M., Yap, F., Eriksson, J.G., Cai, S., Chong, M.F.F., Toh, J.Y., Godfrey, K., Meaney, M.J., and Callaghan, B.L., 2023. Multigenerational adversity impacts on human gut microbiome composition and socioemotional functioning in early childhood. Proceedings of the National Academy of Sciences 120(30): e2213768120. https://doi.org/10.1073/pnas.2213768120
Ran, Y., Long, J., Xu, Z., Yin, Y., Hu, D., Long, X., Zhang, Y., Liang, L., Liang, H. and Guan, B.O., 2021. Harmonic optical microfiber Bragg grating immunosensor for the accelerative test of cardiac biomarker (cTn-I). Biosensors and Bioelectronics 179: 113081. https://doi.org/10.1016/j.bios.2021.113081
Rashidi, A., Ebadi, M., Weisdorf, D.J., Costalonga, M., and Staley, C., 2021. No evidence for colonization of oral bacteria in the distal gut in healthy adults. Proceedings of the National Academy of Sciences 118(42): e2114152118. https://doi.org/10.1073/pnas.2114152118
Remes-Troche, J.M., Taboada-Liceaga, H., Gill, S., Amieva-Balmori, M., Rossi, M., Hernández-Ramírez, G., García-Mazcorro, J.F. and Whelan, K., 2021. Nopal fiber (Opuntia ficus-indica) improves symptoms in irritable bowel syndrome in the short term: a randomized controlled trial. Neurogastroenterology & Motility 33(2): e13986. https://doi.org/10.1111/nmo.13986
Reynolds, A.N., Akerman, A., Kumar, S., Diep Pham, H.T., Coffey, S. and Mann, J., 2022. Dietary fibre in hypertension and cardiovascular disease management: systematic review and meta-analyses. BMC Medicine 20(1): 139. https://doi.org/10.1186/s12916-022-02328-x
Rezende, E.S.V., Lima, G.C. and Naves, M.M.V., 2021. Dietary fibers as beneficial microbiota modulators: a proposed classification by prebiotic categories. Nutrition 89: 111217. https://doi.org/10.1016/j.nut.2021.111217
Rinninella, E., Raoul, P., Cintoni, M., Franceschi, F., Miggiano, G.A.D., Gasbarrini, A. and Mele, M.C., 2019. What is the healthy gut microbiota composition? A changing ecosystem across age, environment, diet, and diseases. Microorganisms 7(1): 14. https://doi.org/10.3390/microorganisms7010014
Rowan, S., Jiang, S., Korem, T., Szymanski, J., Chang, M.-L., Szelog, J., Cassalman, C., Dasuri, K., McGuire, C., Nagai, R., Du, X.-L., Brownlee, M., Rabbani, N., Thornalley, P.J., Baleja, J.D., Deik, A.A., Pierce, K.A., Scott, J.M., Clish, C.B., Smith, D.E., Weinberger, A., Avnit-Sagi, T., Lotan-Pompan, M., Segal, E., and Taylor, A., 2017. Involvement of a gut–retina axis in protection against dietary glycemia-induced age-related macular degeneration. Proceedings of the National Academy of Sciences 114(22): E4472–E4481. https://doi.org/10.1073/pnas.1702302114
Ruscica, M., Penson, P.E., Ferri, N., Sirtori, C.R., Pirro, M., Mancini, G.J., Sattar, N., Toth, P.P., Sahebkar, A., Lavie, C.J. and Wong, N.D., 2021. Impact of nutraceuticals on markers of systemic inflammation: potential relevance to cardiovascular diseases—a position paper from the International Lipid Expert Panel (ILEP). Progress in Cardiovascular Diseases 67: 40–52. https://doi.org/10.1016/j.pcad.2021.06.010
Sagmeister, T., Gubensäk, N., Buhlheller, C., Grininger, C., Eder, M., Ðordić, A., Millán, C., Medina, A., Sánchez Murcia, P.A., Berni, F., Hynönen, U., Vejzović, D., Damisch, E., Kulminskaya, N., Petrowitsch, L., Oberer, M., Palva, A., Malanović, N., Codée, J., Keller, W., Usón, I., and Pavkov-Keller, T., 2024. The molecular architecture of Lactobacillus S-layer: assembly and attachment to teichoic acids. Proceedings of the National Academy of Sciences 121(24): e2401686121. https://doi.org/10.1073/pnas.2401686121
Salamone, D., Rivellese, A.A. and Vetrani, C., 2021. The relationship between gut microbiota, short-chain fatty acids and type 2 diabetes mellitus: the possible role of dietary fibre. Acta Diabetologica 58(9): 1131–1138. https://doi.org/10.1007/s00592-021-01727-5
Schimmel, K., Ichimura, K., Reddy, S., Haddad, F. and Spiekerkoetter, E., 2022. Cardiac fibrosis in the pressure overloaded left and right ventricle as a therapeutic target. Frontiers in Cardiovascular Medicine 9: 886553. https://doi.org/10.3389/fcvm.2022.886553
Schlesinger, S., 2022. Diet and diabetes prevention: is a plant-based diet the solution? Diabetes Care 46(1): 6. https://doi.org/10.2337/dci22-0041
Schut, G.J., Thorgersen, M.P., Poole, F.L., Haja, D.K., Putumbaka, S., and Adams, M.W., 2021. Tungsten enzymes play a role in detoxifying food and antimicrobial aldehydes in the human gut microbiome. Proceedings of the National Academy of Sciences 118(43): e2109008118. https://doi.org/10.1073/pnas.2109008118
Semenkovich, N.P., Planer, J.D., Ahern, P.P., Griffin, N.W., Lin, C.Y., and Gordon, J.I., 2016. Impact of the gut microbiota on enhancer accessibility in gut intraepithelial lymphocytes. Proceedings of the National Academy of Sciences 113(51): 14805–14810. https://doi.org/10.1073/pnas.1617793113
Sequeira, S., Kavanaugh, D., MacKenzie, D.A., Šuligoj, T., Walpole, S., Leclaire, C., Gunning, A.P., Latousakis, D., Willats, W.G.T., Angulo, J., Dong, C., and Juge, N., 2018. Structural basis for the role of serine-rich repeat proteins from Lactobacillus reuteri in gut microbe–host interactions. Proceedings of the National Academy of Sciences 115(12): E2706–E2715. https://doi.org/10.1073/pnas.1715016115
Seradj, A.R., Balcells, J., Morazan, H., Alvarez-Rodriguez, J., Babot, D. and De la Fuente, G., 2018. The impact of reducing dietary crude protein and increasing total dietary fiber on hindgut fermentation, the methanogen community and gas emission in growing pigs. Animal Feed Science and Technology 245: 54–66. https://doi.org/10.1016/j.anifeedsci.2018.09.005
Shah, B.R., Li, B., Al Sabbah, H., Xu, W. and Mráz, J., 2020. Effects of prebiotic dietary fibers and probiotics on human health: with special focus on recent advancement in their encapsulated formulations. Trends in Food Science & Technology 102: 178–192. https://doi.org/10.1016/j.tifs.2020.06.010
Shearrer, G.E., O'Reilly, G.A., Belcher, B.R., Daniels, M.J., Goran, M.I., Spruijt-Metz, D. and Davis, J.N., 2016. The impact of sugar sweetened beverage intake on hunger and satiety in minority adolescents. Appetite 97: 43–48. https://doi.org/10.1016/j.appet.2015.11.015
Shen, W., Sun, J., Li, Z., Yao, F., Lin, K. and Jiao, X., 2020. Food intake and its effect on the species and abundance of intestinal flora in colorectal cancer and healthy individuals. Korean Journal of Internal Medicine 36(3): 568. https://doi.org/10.3904/kjim.2019.373
So, W.K., Chan, J.Y., Law, B.M., Choi, K.C., Ching, J.Y., Chan, K.L., Tang, R.S., Chan, C.W., Wu, J.C. and Tsui, S.K., 2021b. Effects of a rice bran dietary intervention on the composition of the intestinal microbiota of adults with a high risk of colorectal cancer: a pilot randomised-controlled trial. Nutrients 13(2): 526. https://doi.org/10.3390/nu13020526
Singh, S., Sharma, P., Pal, N., Kumawat, M., Shubham, S., Sarma, D.K., Tiwari, R.R., Kumar, M. and Nagpal, R., 2022 . Impact of environmental pollutants on gut microbiome and mental health via the gut–brain axis. Microorganisms, 10(7): 1457. https://doi.org/10.3390/microorganisms10071457
So, D., Gibson, P.R., Muir, J.G. and Yao, C.K., 2021a. Dietary fibres and IBS: translating functional characteristics to clinical value in the era of personalised medicine. Gut 70(12): 2383–2394. https://doi.org/10.1136/gutjnl-2021-324891
Sowah, S.A., Milanese, A., Schübel, R., Wirbel, J., Kartal, E., Johnson, T.S., Hirche, F., Grafetstätter, M., Nonnenmacher, T., Kirsten, R. and López-Nogueroles, M., 2022. Calorie restriction improves metabolic state independently of gut microbiome composition: a randomized dietary intervention trial. Genome Medicine 14(1): 30. https://doi.org/10.1186/s13073-022-01030-0
Spencer, C.N., McQuade, J.L., Gopalakrishnan, V., McCulloch, J.A., Vetizou, M., Cogdill, A.P., Khan, M.A.W., Zhang, X., White, M.G., Peterson, C.B. and Wong, M.C., 2021. Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response. Science 374(6575): 1632–1640. https://doi.org/10.1126/science.aaz7015
Stephen, A.M., Champ, M.M.J., Cloran, S.J., Fleith, M., Van Lieshout, L., Mejborn, H. and Burley, V.J., 2017. Dietary fibre in Europe: current state of knowledge on definitions, sources, recommendations, intakes and relationships to health. Nutrition Research Reviews 30(2): 149–190. https://doi.org/10.1017/S095442241700004X
Sun, J., Chen, S., Zang, D., Sun, H., Sun, Y. and Chen, J., 2024. Butyrate as a promising therapeutic target in cancer: from pathogenesis to clinic. International Journal of Oncology 64(4): 44. https://doi.org/10.3892/ijo.2024.5632
Suresh, A., Shobna, Salaria, M., Morya, S., Khalid, W., Afzal, F.A., Khan, A.A., Safdar, S., Khalid, M.Z. and Mukonzo Kasongo, E.L., 2024. Dietary fiber: an unmatched food component for sustainable health. Food and Agricultural Immunology 35(1): 2384420. https://doi.org/10.1080/09540105.2024.2384420
Tan, W.S.K., Chia, P.F.W., Ponnalagu, S., Karnik, K. and Henry, C.J., 2020. The role of soluble corn fiber on glycemic and insulin response. Nutrients 12(4): 961. https://doi.org/10.3390/nu12040961
Tanes, C., Bittinger, K., Gao, Y., Friedman, E.S., Nessel, L., Paladhi, U.R., Chau, L., Panfen, E., Fischbach, M.A., Braun, J. and Xavier, R.J., 2021. Role of dietary fiber in the recovery of the human gut microbiome and its metabolome. Cell Host & Microbe 29(3): 394–407. https://doi.org/10.1016/j.chom.2020.12.012
Tang, W.W., Kitai, T. and Hazen, S.L., 2017. Gut microbiota in cardiovascular health and disease. Circulation Research 120(7): 1183–1196. https://doi.org/10.1161/CIRCRESAHA.117.309715
Tangestani, H., Emamat, H., Ghalandari, H. and Shab-Bidar, S., 2020. Whole grains, dietary fibers and the human gut microbiota: a systematic review of existing literature. Recent Patents on Food, Nutrition & Agriculture 11(3): 235–248. https://doi.org/10.2174/2212798411666200316152252
Tao, J., Li, S., Gan, R.Y., Zhao, C.N., Meng, X. and Li, H.B., 2020. Targeting gut microbiota with dietary components on cancer: effects and potential mechanisms of action. Critical Reviews in Food Science and Nutrition 60(6): 1025–1037. https://doi.org/10.1080/10408398.2018.1555789
Thomson, C.A., Crane, T.E., Miller, A., Gold, M.A., Powell, M., Bixel, K., Van Le, L., DiSilvestro, P., Ratner, E., Lele, S. and Guntupalli, S., 2023. Lifestyle intervention in ovarian cancer enhanced survival (LIVES) study (NRG/GOG0225): recruitment, retention and baseline characteristics of a randomized trial of diet and physical activity in ovarian cancer survivors. Gynecologic Oncology 170: 11–18. https://doi.org/10.1016/j.ygyno.2022.12.017
Thompson, S.V., Hannon, B.A., An, R. and Holscher, H.D., 2017. Effects of isolated soluble fiber supplementation on body weight, glycemia, and insulinemia in adults with overweight and obesity: a systematic review and meta-analysis of randomized controlled trials. American Journal of Clinical Nutrition 106(6): 1514–1528. https://doi.org/10.3945/ajcn.117.163246
Tobar, N., Rocha, G.Z., Santos, A., Guadagnini, D., Assalin, H.B., Camargo, J.A., Gonçalves, A.E.S.S., Pallis, F.R., Oliveira, A.G., Rocco, S.A., Neto, R.M., Sousa, I.L., Alborghetti, M.R., Sforça, M.L., Rodrigues, P.B., Ludwig, R.G., Vanzela, E.C., Brunetto, S.Q., Boer, P.A., Gontijo, J.A.R., Geloneze, B., Carvalho, C.R.O., Prada, P.O., Folli, F., Curi, R., Mori, M.A., Vinolo, M.A.R., Ramos, C.D., Franchini, K.G., Tormena, C.F., and Saad, M.J., 2023. Metformin acts in the gut and induces gut–liver crosstalk. Proceedings of the National Academy of Sciences 120(4): e2211933120. https://doi.org/10.1073/pnas.2211933120
Tosh, S.M. and Bordenave, N., 2020. Emerging science on benefits of whole grain oat and barley and their soluble dietary fibers for heart health, glycemic response, and gut microbiota. Nutrition Reviews 78(Supplement 1): 13–20. https://doi.org/10.1093/nutrit/nuz085
Townsend, G.E., Han, W., Schwalm III, N.D., Raghavan, V., Barry, N.A., Goodman, A.L., and Groisman, E.A., 2019. Dietary sugar silences a colonization factor in a mammalian gut symbiont. Proceedings of the National Academy of Sciences 116(1): 233–238. https://doi.org/10.1073/pnas.1813780115
Trautwein, E.A. and McKay, S., 2020. The role of specific components of a plant-based diet in management of dyslipidemia and the impact on cardiovascular risk. Nutrients 12(9): 2671. https://doi.org/10.3390/nu12092671
Tremblay, A., Clinchamps, M., Pereira, B., Courteix, D., Lesourd, B., Chapier, R., Obert, P., Vinet, A., Walther, G., Chaplais, E. and Bagheri, R., 2020. Dietary fibres and the management of obesity and metabolic syndrome: the RESOLVE study. Nutrients 12(10): 2911. https://doi.org/10.3390/nu12102911
Trevelline, B.K., and Kohl, K.D., 2022. The gut microbiome influences host diet selection behavior. Proceedings of the National Academy of Sciences 119(17): e2117537119. https://doi.org/10.1073/pnas.2117537119
Turner, N.D. and Lupton, J.R., 2021. Dietary fiber. Advances in Nutrition 12(6): 2553–2555. https://doi.org/10.1093/advances/nmab116
Ureña, E., Xu, B., Regan, J.C., Atilano, M.L., Minkley, L.J., Filer, D., Lu, Y.-X., Bolukbasi, E., Khericha, M., Alic, N., and Partridge, L., 2024. Trametinib ameliorates aging-associated gut pathology in Drosophila females by reducing Pol III activity in intestinal stem cells. Proceedings of the National Academy of Sciences 121(4): e2311313121. https://doi.org/10.1073/pnas.2311313121
van Trijp, M.P., Schutte, S., Esser, D., Wopereis, S., Hoevenaars, F.P., Hooiveld, G.J. and Afman, L.A., 2021. Minor changes in the composition and function of the gut microbiota during a 12-week whole grain wheat or refined wheat intervention correlate with liver fat in overweight and obese adults. Journal of Nutrition 151(3): 491–502. https://doi.org/10.1093/jn/nxaa312
Venter, C., Meyer, R.W., Greenhawt, M., Pali-Schöll, I., Nwaru, B., Roduit, C., Untersmayr, E., Adel-Patient, K., Agache, I., Agostoni, C. and Akdis, C.A., 2022. Role of dietary fiber in promoting immune health—an EAACI position paper. Allergy 77(11): 3185–3198. https://doi.org/10.1111/all.15430
Vinelli, V., Biscotti, P., Martini, D., Del Bo’, C., Marino, M., Meroño, T., Nikoloudaki, O., Calabrese, F.M., Turroni, S., Taverniti, V. and Unión Caballero, A., 2022. Effects of dietary fibers on short-chain fatty acids and gut microbiota composition in healthy adults: a systematic review. Nutrients 14(13): 2559. https://doi.org/10.3390/nu14132559
Waddell, I.S. and Orfila, C., 2023. Dietary fiber in the prevention of obesity and obesity-related chronic diseases: from epidemiological evidence to potential molecular mechanisms. Critical Reviews in Food Science and Nutrition 63(27): 8752–8767. https://doi.org/10.1080/10408398.2022.2061909
Wang, M., Wichienchot, S., He, X., Fu, X., Huang, Q. and Zhang, B., 2019. In vitro colonic fermentation of dietary fibers: fermentation rate, short-chain fatty acid production and changes in microbiota. Trends in Food Science & Technology 88: 1–9. https://doi.org/10.1016/j.tifs.2019.03.005
Wang, L., Xu, H., Yuan, F., Pan, Q., Fan, R. and Gao, Y., 2015. Physicochemical characterization of five types of citrus dietary fibers. Biocatalysis and Agricultural Biotechnology 4(2): 250–258. https://doi.org/10.1016/j.bcab.2015.02.003
Wang, B., Yu, H., He, Y., Wen, L., Gu, J., Wang, X., Miao, X., Qiu, G. and Wang, H., 2021. Effect of soybean insoluble dietary fiber on prevention of obesity in high-fat diet fed mice via regulation of the gut microbiota. Food & Function 12(17): 7923–7937. https://doi.org/10.1039/D1FO00078K
Watkins, A.J., Dias, I., Tsuro, H., Allen, D., Emes, R.D., Moreton, J., Wilson, R., Ingram, R.J.M., and Sinclair, K.D., 2018. Paternal diet programs offspring health through sperm- and seminal plasma-specific pathways in mice. Proceedings of the National Academy of Sciences 115(40): 10064–10069. https://doi.org/10.1073/pnas.1806333115
Wei, N., Wang, L., Tang, B., Huang, Y. and Xuan, L., 2024. A global analysis of the burden of ischemic heart disease attributable to diet low in fiber between 1990 and 2019. BMC Cardiovascular Disorders 24(1): 491. https://doi.org/10.1186/s12872-024-04156-8
Wexler, A.G., Bao, Y., Whitney, J.C., Bobay, L.-M., Xavier, J.B., Schofield, W.B., Barry, N.A., Russell, A.B., Tran, B.Q., Goo, Y.A., Goodlett, D.R., Ochman, H., Mougous, J.D., and Goodman, A.L., 2016. Human symbionts inject and neutralize antibacterial toxins to persist in the gut. Proceedings of the National Academy of Sciences 113(13): 3639–3644. https://doi.org/10.1073/pnas.1525637113
Whisner, C.M., Martin, B.R., Nakatsu, C.H., Story, J.A., MacDonald-Clarke, C.J., McCabe, L.D., McCabe, G.P. and Weaver, C.M., 2016. Soluble corn fiber increases calcium absorption associated with shifts in the gut microbiome: a randomized dose-response trial in free-living pubertal females. Journal of Nutrition 146(7): 1298–1306. https://doi.org/10.3945/jn.115.227256
Wiertsema, S.P., van Bergenhenegouwen, J., Garssen, J. and Knippels, L.M., 2021. The interplay between the gut microbiome and the immune system in the context of infectious diseases throughout life and the role of nutrition in optimizing treatment strategies. Nutrients 13(3): 886. https://doi.org/10.3390/nu13030886
Wu, S., Jia, W., He, H., Yin, J., Xu, H., He, C., Zhang, Q., Peng, Y. and Cheng, R., 2023. A new dietary fiber can enhance satiety and reduce postprandial blood glucose in healthy adults: a randomized cross-over trial. Nutrients 15(21): 4569. https://doi.org/10.3390/nu15214569
Xie, Y., Gou, L., Peng, M., Zheng, J. and Chen, L., 2021. Effects of soluble fiber supplementation on glycemic control in adults with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. Clinical Nutrition 40(4): 1800–1810. https://doi.org/10.1016/j.clnu.2020.10.032
Yasukawa, Z., Inoue, R., Ozeki, M., Okubo, T., Takagi, T., Honda, A. and Naito, Y., 2019. Effect of repeated consumption of partially hydrolyzed guar gum on fecal characteristics and gut microbiota: a randomized, double-blind, placebo-controlled, and parallel-group clinical trial. Nutrients 11(9): 2170. https://doi.org/10.3390/nu11092170
Ye, S., Shah, B.R., Li, J., Liang, H., Zhan, F., Geng, F. and Li, B., 2022. A critical review on interplay between dietary fibers and gut microbiota. Trends in Food Science & Technology 124: 237–249. https://doi.org/10.1016/j.tifs.2022.04.010
Zanotelli, M.R., Miller, J.P., Wang, W., Ortiz, I., Tahon, E., Bordeleau, F. and Reinhart-King, C.A., 2024. Tension directs cancer cell migration over fiber alignment through energy minimization. Biomaterials 311: 122682. https://doi.org/10.1016/j.biomaterials.2024.122682
Zeng, Y., Pu, X., Yang, J., Du, J., Yang, X., Li, X., Li, L., Zhou, Y. and Yang, T., 2018. Preventive and therapeutic role of functional ingredients of barley grass for chronic diseases in human beings. Oxidative Medicine and Cellular Longevity 2018(1): 3232080. https://doi.org/10.1155/2018/3232080
Zeng H, Lazarova DL, Bordonaro M. Mechanisms linking dietary fiber, gut microbiota and colon cancer prevention. World Journal of Gastrointestinal Oncology, 2014 16(2): 41. https://doi.org/10.4251/wjgo.v6.i2.41
Zhang, P., 2022. Influence of foods and nutrition on the gut microbiome and implications for intestinal health. International Journal of Molecular Sciences 23(17): 9588. https://doi.org/10.3390/ijms23179588
Zhang, F., Fan, D., Huang, J.L. and Zuo, T., 2022. The gut microbiome: linking dietary fiber to inflammatory diseases. Medicine in Microecology 14: 100070. https://doi.org/10.1016/j.medmic.2022.100070
Zhang, X. and Gérard, P., 2022. Diet-gut microbiota interactions on cardiovascular disease. Computational and Structural Biotechnology Journal 20: 1528–1540. https://doi.org/10.1016/j.csbj.2022.03.028
Zhang, Y., Li, Y., Barber, A.F., Noya, S.B., Williams, J.A., Li, F., Daniel, S.G., Bittinger, K., Fang, J., and Sehgal, A., 2023. The microbiome stabilizes circadian rhythms in the gut. Proceedings of the National Academy of Sciences 120(5): e2217532120. https://doi.org/10.1073/pnas.2217532120
Zou, J., Reddivari, L., Shi, Z., Li, S., Wang, Y., Bretin, A., Ngo, V.L., Flythe, M., Pellizzon, M., Chassaing, B. and Gewirtz, A.T., 2021. Inulin fermentable fiber ameliorates type I diabetes via IL22 and short-chain fatty acids in experimental models. Cellular and Molecular Gastroenterology and Hepatology 12(3): 983–1000. https://doi.org/10.1016/j.jcmgh.2021.04.014