Rapid lateral flow tests in a Hazard Analysis of Critical Control Points-based approach for allergen monitoring

Main Article Content

Mareike Richter
Sigrid Haas-Lauterbach
Karl Schmitt


allergens, analytical methods, food safety, rapid methods


Allergen management in food companies is now becoming increasingly important. Under Article 5 of the European Commission Hygiene Code 852/2004, food companies are required to introduce, carry out and maintain regular hygiene controls based on Hazard Analysis of Critical Control Points principles. The Codex Alimentarius contains a general description of the Hazard Analysis of Critical Control Points principles. Thus, Hazard Analysis of Critical Control Points is defined as a system, which is designed to identify the health risks from food and to implement preventive measures for their control. With sensitive people, even slight traces of allergens can trigger an allergic reaction, which may result in anaphylactic shock in the severest cases, and this can be lethal if untreated. To ensure food safety for consumer protection, the products must be correctly labelled and cross-contamination by contaminated raw materials, in production processes, during storage or transportation must be prevented. R-Biopharm supports food companies when optimizing the allergen management system by offering rapid allergen tests for analysing processes. Food manufacturers should use fast and reliable processes to check for allergen contamination in food production. The increased importance of these detection methods is indicated by the current debate and the fact that some of these methods have been officially validated and approved.

Abstract 54 | PDF Downloads 19


Codex Alimentarius Commission (CAC). (1993) Twentieth Session Geneva 28 June–7 July 1993, Report of the Twenty-second Session of the Codex Committee on Food Labelling. Ottawa, Canada, 26–30 April 1993 ALINORM 93/22 AppendixIV, Annex, pp. 59.
Diaz-Amigo C., P ?opping B. (2010) Analytical testing as a tool for the enforcement of future regulatory thresholds for food allergens. Journal of AOAC International, 93, 434–441.
Grundy J., Matthews S., Bateman B., Dean T., Arshad S. (2002) Rising prevalence of allergy to peanut in children: data from 2 sequential cohorts. Journal of Allergy and Clinical Immunology,110, 784–789.
Lineback D.R., Pirlet A., Van der Kamp J.-W., Wood R. (2008) Quality Assurance and Safety of Crops & Foods,1, 23–27.
Osman A.A., Uhlig H.H., Valdes I., Amin M., M ?endez E., MothesT. (2001) A monoclonal antibody that recognizes a potential celiac-toxic repetitive pentapeptide epitope in gliadins. European Journal of Gastroenterological Hepathology,13,1189–1193.
R ?oder M., Vieths S., Holzhauser T. (2009) Commercial lateral flow devices for rapid detection of peanut (Arachis hypogeae) and hazelnut (Corylus avellana) cross-contamination in the industrial production of cookies. Analytical and Bioanalytical Chemistry,395, 103–109.
Sicherer S.H., Munoz-Furlong A., Sampson H.A. (2003) Prevalence of peanut and tree nut allergy in the United States determined by means of a random digit dial trelphone survey: a 5-year follow-up study. Journal of Allergy and Clinical Immunology,112, 1203–1207.
Sicherer S.H., Munoz-Furlong A., Sampson H.A. (2004) Prevalence of seafood allergy in the United States determined by random telephone survey. Journal of Allergy and Clinical Immunology, 114, 159–165.
Staatskoerant. (2007) Foodstuffs, Cosmetic and Disinfectants Act, 1972 (Act 54 of 1972), Regulations relating to the labeling and advertising of foodstuffs, no. 30075 69, July 20
Taylor S.L., Gendel S.M., Houben G.F., Julien E. (2009a) The key events dose–response framework: a foundation for examining variability in elicitation thresholds for food allergens. Critical Review in Food Science and Nutrition, 49, 682–689.
Taylor S.L., Hefle S.L. (2005) Allergen Control – Increased awareness of food allergies is leading food companies to develop comprehensive allergen control programs. Here’swhat’s involved. Food Technology, 59, 40–43.
Taylor S.L., Hefle S.L., Bindslev-Jensen C., Bock S.A., Boulder A,Burks Jr.W., Christie L., Hill D.J., Host A., Lack G.,Metcalfe D.D., Moneret-Vautrin D.A., Vadas P.A., Rance F.,Skrypec D.J., Trautman T.A., Robert I., Zeiger S. (2002) Factors affecting the determination of threshold doses for allergenic foods: How much is too much?Journal of Allergy and Clinical Immunology,109,24–30.
Taylor S.L., Nordlee J.A., Niemann L.M., Lambrecht D.M.(2009b) Allergen immunoassay – considerations for use of naturally incurred standards. Analytical and Bioanalytical Chemistry,395, 83–92.