Determination and safety evaluation of metal element contents of Oviductus Ranae produced from Rana dybowskii by pond culture–forest grazing relay model in Heilongjiang Province, China
Main Article Content
Keywords
Oviductus Ranae, metal element, safety evaluation, recommended safe dosage
Abstract
The aquatic products of grazing ecological culture exhibit a strong reliance on the production environment system, which may result in heavy metal contamination. In this study, 24 elements (Ag, Al, As, Ba, Cd, Co, Cr, Cs, Cu, Fe, Ga, K, Mg, Mn, Na, Ni, Pb, Rb, Se, Sr, Tl, U, V, Zn) were determined for Oviductus Ranae (OR) from more than 1,000 individuals of Rana dybowskii produced by pond culture–forest grazing relay mode from six major production areas in Heilongjiang Province, China. Furthermore, we assessed the associated health risks. Our findings indicate that most of these 24 metal elements were detected in OR at a detection rate of 100%, with the exceptions being As (98.0%), Ga (98.0%), Co (98.0%), V (94.0%), Cd (89.0%), Pb (76.0%), Cs (74.0%), Tl (35.0%), and U (not detectable). Variations in element concentrations were significant across the six sampling sites, with characteristic elements identified to account for spatial differences. The total target hazard quotient was determined to be 0.152 in Heilongjiang Province, thereby suggesting a relatively low health risk associated with consuming OR from this region’s production systems according to existing standards and guidelines. Nevertheless, special attention is needed for monitoring the habitat environments of R. dybowskii from two sampling locations showing heightened pollution levels.
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Briffa, J., Sinagra, E. and Blundell, R., 2020. Heavy metal pollution in the environment and their toxicological effects on humans. Heliyon, 6, e04691.
Chen, F., Luan, P., Li, M., Zhang, T., Shu, Y. and Hu, G., 2023. Transcriptome analysis reveals cross-tissue metabolic pathway changes in female Rana dybowskii during emergence from hibernation. Fishes, 8, 569.
ChP. People’s Republic of China, State Administration for Market Regulation, 2020. Pharmacopoeia of the People’s Republic of China [Ch. 2020 Edition]. Beijing, China: Chemical Industry Press.
Fan, C., Liu, Y., Wang, Y., Zhang, A., Xie, W., Zhang, H., et al., 2022. Expression of glycogenic genes in the oviduct of Chinese brown frog (Rana dybowskii) during pre-brumation. Theriogenology, 185, 78–87.
GB 2762–2022. National standards for food safety. PRC, Standards Press of China, Beijing, China.
GB/T 19507–2008. Product of geographical indication–Jilin Changbaishan forest frog’s oviduct. PRC, Standards Press of China, Beijing, China.
Han, X., Zhu, J. and Yu, P., 2018. Correlation analysis of heavy metals in Rana chensinensis and their environment. Chinese Journal of Wildlife, 39, 633–638.
Hu, G., Luan, P., and Guo, J., 2022. Conservation and utilization status for forest frog resources in northeast China: a review. Chinese Journal of Fisheries, 35, 93–97.
Igbokwe, I.O., Igwenagu, E. and Igbokwe, N.A., 2019. Aluminium toxicosis: a review of toxic actions and effects. Interdisciplinary Toxicology, 12, 45–70.
JECFA (Joint FAO/WHO Expert Committee on Food Additives), 2011. In: Organization, F.a.A (Ed.), Provisional Tolerable Daily Intake (PTDI) of Proposed (ed).
Li, T., 2014. The study of rana oviduct consumption’s safety and safe dose in food science. Liaoning University.
Mitra, S., Chakraborty, A.J., Tareq, A.M., Emran, T.B., Nainu, F., Khusro, et al., 2022. Impact of heavy metals on the environment and human health: Novel therapeutic insights to counter the toxicity. Journal of King Saud University–Science, 34, 101865.
Muhammad, U.A., Wang, C., Li, Y., Li. R., Yang, S., Ding, L., et al., 2023. Heavy metals in fish, rice, and human hair and health risk assessment in Wuhan city, Central China Environmental Pollution, 328, 121604.
Noverita, D.T., Anna, I.P. and Yulianto, S., 2021. Cadmium (Cd), copper (Cu), and zinc (Zn) levels in commercial and non-commercial fishes in the Blanakan river estuary, Indonesia: a preliminary study. Marine Pollution Bulletin, 170, 112607.
NY 5073–2006. The Agriculture in China industry standard. PRC., Standards Press of China, Beijing, China.
NY/T 1516–2020. Green food-Frog and its processed products. PRC, Standards Press of China, Beijing, China.
Piñeiro, V., Arias, J., Dürr, J., Elverdin, P., Ibáñez, A.M., Kinengyere, A., et al., 2020. A scoping review on incentives for adoption of sustainable agricultural practices and their outcomes. Nature Sustainability, 3, 809–820.
Rahimzadeh, M.R., Rahimzadeh, M.R., Kazemi, S., Amiri, R.J., Pirzadeh, M., and Moghadamnia, A.A., 2022. Aluminum poisoning with emphasis on its mechanism and treatment of intoxication. Emergency Medical International, 1480553.
Shang, Y., Wang, D. and Wen, H., 2019. Characteristic analysis on inorganic and heavy metal elements contents of different regions of Oviductus Ranae. Food Research and Development, 40, 170–175.
Sheng, Y. and Song, L., 2019. Agricultural production and food consumption in China: A long-term projection. China Economic Review, 53, 15–29.
Tang, S., Song, D., Bai, S., Huang, X., Chen, Z., Wang, P., et al., 2023. Trace elements accumulation and health risk assessment of Chinese mitten crab (Eriocheir sinensis) from monoculture and rice-crab co-culture mode. Journal of Food Composition and Analysis, 123, 105640.
USEPA (U.S. Environmental Protection Agency), 2016. In: U.S.E.P.A.N.C.f.E (Ed.), Integrated Risk Information System (IRIS) Chemical Assessment Summary. Assessment. Retrieved from: https://www.epa (Accessed: May 1, 2023).
Wang, J., Xiao, X., Chai, L., Wang, B., Xu, M., and Qu, L., 2017. Heavy metals in Oviductus Ranae and its safety as a food product. Chinese Journal of Wildlife, 38, 648–653.
Wang, Q., Fan, Z., Qiu, L., Liu, X., Yin, Y., Ibrahim Jamus, I.M., et al., 2021. Occurrence and health risk assessment of residual heavy metals in the Chinese mitten crab (Eriocheir sinensis). Journal of Food Composition and Analysis, 97, 103787.
Wang, Z.Y., Zhou, Y., Ruan, P.Y., Wang, S.H., Zhang, C.L., Wang, Z.H., et al., 2023. Impact of breeding environments on the fatty acid composition of Rana chensinensis ovum from Changbai Mountain based on UPLC-Q/TOF-MS analysis. Journal of Food Composition and Analysis, 123, 105599.
Wei, H., Geng, L., Shang, X., Hu, G., Luan, P., and Xu, W., 2023. Background color preference of Amphibian Rana dybowskii. Applied Animal Behaviour Science, 106079.
Witkowska, D., Słowik, J. and Chilicka, K., 2021. Heavy metals and human health: possible exposure pathways and the competition for protein binding sites. Molecules, 26.
Zaynab, M., Al-Yahyai, R., Ameen, A., Sharif, Y., Ali, L., Fatima, M., et al., 2022. Health and environmental effects of heavy metals. Journal of King Saud University–Science, 34, 101653.
Zhang, C., Miao, X., Du, S., Zhang, T., Chen, L., Liu, Y., et al., 2023. Effects of culinary procedures on concentrations and bioaccessibility of Cu, Zn, and as in different food ingredients. Foods, 12, 1653.
Zhang, H., Ma, X., Su, H., Sui, H., Shi, X., Li, X., et al., 2018. Soil heavy metal background values and pollution degree in southern songnen plain of heilongjiang province. Agricultural Research in the Arid Areas, 6(36): 230–236.
Zhang, M., Jia, X., Ma, Y. and Ma, J., 2010. Genetic diversity and differentiation of the Dybowski’s frog (Rana dybowskii) in Northeast China. Journal of Forestry Research, 21, 239–245.
Zhang, W.Q., Guo, S., Zhou, L., Xie, D., Xin, M., Hu, Y.X., et al., 2024. Multi-omics analysis reveals the healthy functions of Oviductus Ranae. Pharmacological Research–Modern Chinese Medicine, 10, 100369.
Zhang, Y., Wang, Y., Li, M., Liu, S., Yu, J., Yan, Z., et al., 2019. Traditional uses, bioactive constituents, biological functions, and safety properties of Oviductus ranae as functional foods in China. Oxidative Medicine and Cellular Longevity, 2019, 4739450.
Zhao, Y., Zhang, Z., Li, B., Zhao, Y., Lu, J., and Tang, X., 2021. Accurate determination and comprehensive evaluation of heavy metals in different soils from Jilin province in northeast China. Analytical Letters, 12(54): 1901–1928.
Zoroddu, M.A., Aaseth, J., Crisponi, G., Medici, S., Peana, M., and Nurchi, V.M., 2019. The essential metals for humans: a brief overview. Journal of Inorganic Biochemistry, 195, 120–129.
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Sep 8, 2024
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How to Cite
Tang, S., Luan, P., Chen, F., Wang, P., Qin, D., Chen, Z., & Hu, G. (2024). Determination and safety evaluation of metal element contents of Oviductus Ranae produced from Rana dybowskii by pond culture–forest grazing relay model in Heilongjiang Province, China. Quality Assurance and Safety of Crops & Foods, 16(3), 111-126. https://doi.org/10.15586/qas.v16i3.1443
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Research Article
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
How to Cite
Tang, S., Luan, P., Chen, F., Wang, P., Qin, D., Chen, Z., & Hu, G. (2024). Determination and safety evaluation of metal element contents of Oviductus Ranae produced from Rana dybowskii by pond culture–forest grazing relay model in Heilongjiang Province, China. Quality Assurance and Safety of Crops & Foods, 16(3), 111-126. https://doi.org/10.15586/qas.v16i3.1443